Search Results
Overview
| Uniprot ID | A8U4R4 |
|---|---|
| Protein Name | Transketolase |
| Gene Name | tkt |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | AELLNLRKISSDLDG |
| 144 | YTGKYFDKASYRVYC |
| 16 | QQKLQALKDTANRLR |
| 204 | HQMDVYQKRCEAFGW |
| 232 | CKAFGQVKNQPTAII |
| 241 | QPTAIIAKTFKGRGI |
| 254 | GITGVEDKESWHGKP |
| 283 | SQIQNKKKILATPPQ |
| 310 | MPTPPSYKVGDKIAT |
| 314 | PSYKVGDKIATRKAY |
| 319 | GDKIATRKAYGQALA |
| 327 | AYGQALAKLGHASDR |
| 538 | VLDPFTVKPLDRKLI |
| 543 | TVKPLDRKLILDSAR |
| 59 | FFHTMRYKAQDPRNP |
| 609 | LKMFGIDKDAIARAV |
Function
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Protein Sequence
10
MEAYHKPDQQ
20
KLQALKDTAN
30
RLRISSIQAT
40
TAAGSGHPTS
50
CCSAAEIMAV
60
LFFHTMRYKA
70
QDPRNPHNDR
80
FVLSKGHAAP
90
ILYSVWAEAG
100
FLPEAELLNL
110
RKISSDLDGH
120
PVPKQAFTDV
130
ATGSLGQGLG
140
AACGMAYTGK
150
YFDKASYRVY
160
CLLGDGELSE
170
GAVWEAMAFA
180
GIYKLDNLVA
190
ILDINRLGQS
200
DPAPLQHQMD
210
VYQKRCEAFG
220
WHAIIVDGHS
230
VEELCKAFGQ
240
VKNQPTAIIA
250
KTFKGRGITG
260
VEDKESWHGK
270
PLPQNMADQV
280
IQEIYSQIQN
290
KKKILATPPQ
300
EDAPSVDITN
310
IRMPTPPSYK
320
VGDKIATRKA
330
YGQALAKLGH
340
ASDRIIALDG
350
DTKNSTFSEL
360
FKKEHPDRFI
370
ECYIAEQNMV
380
SIAVGCATRN
390
RTVPFCSTFA
400
AFFTRAFDQI
410
RMAAISESNI
420
NLCGSHCGVS
430
IGEDGPSQMA
440
LEDLAMFRSV
450
PMSTVFYPSD
460
GVATEKAVEL
470
AANTKGICFI
480
RTSRPENAII
490
YNNNEDFQIG
500
QAKVVLKSKD
510
DQVTVIGAGV
520
TLHEALAAAD
530
LLKKEKINIR
540
VLDPFTVKPL
550
DRKLILDSAR
560
ATKGRILTVE
570
DHYYEGGLGE
580
AVAAAVVGEP
590
DVTVTRLAVS
600
QVPRSGKPAE
610
LLKMFGIDKD
620
AIARAVRGLV
TKA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016607 | nuclear speck |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0030976 | thiamine pyrophosphate binding |
| Molecular Function | GO:0004802 | transketolase activity |
| Biological Process | GO:1901159 | D-xylulose 5-phosphate biosynthetic process |
| Biological Process | GO:0046166 | glyceraldehyde-3-phosphate biosynthetic process |
| Biological Process | GO:0009052 | pentose-phosphate shunt, non-oxidative branch |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.