Search Results
Overview
| Uniprot ID | B0BMT9 |
|---|---|
| Protein Name | Sulfide:quinone oxidoreductase, mitochondrial |
| Gene Name | Sqor |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 241 | GTIFGVKKYADALQE |
Function
Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione
Protein Sequence
10
MAPLVAVVSS
20
PRARLFACFL
30
RLGTQQAGPL
40
QLHTGACCTA
50
KNHYEVLVLG
60
GGSGGITMAT
70
RMKRRVGAEN
80
VAIVEPSERH
90
FYQPIWTLVG
100
AGAKELSSSD
110
RSTLSVIPSG
120
VQWIQDRVAE
130
LNPDQNCIRT
140
DNGKEISYRY
150
LIIALGIQLD
160
YEKIKGLPEG
170
FAYPKIGSNY
180
SVKTVEKTWK
190
ALQDFKEGNA
200
LFTFPNTPVK
210
CAGAPQKIMY
220
LSEAYFRKTG
230
KRSKANIIFN
240
TALGTIFGVK
250
KYADALQEII
260
RERNVSVNYK
270
HNLIEVRADK
280
QEAVFENLDK
290
PGETHVIHYE
300
MLHVTPPMSS
310
PDVLKRSPVA
320
DSAGWVDVDK
330
ETLQHKKYPN
340
VFGIGDCTNL
350
PTSKTAAAVA
360
AQSGILDRTI
370
SLIMKNQTPT
380
KKYDGYTSCP
390
LVTGYNRVIL
400
AEFDYTAQPL
410
ETFPFDQSKE
420
RISMYLMKAD
430
MMPFLYWNMM
440
LRGYWGGPAF
450
LRKLFHLGLS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0071949 | FAD binding |
| Molecular Function | GO:0106436 | glutathione-dependent sulfide quinone oxidoreductase activity |
| Molecular Function | GO:0048038 | quinone binding |
| Molecular Function | GO:0070224 | sulfide:quinone oxidoreductase activity |
| Biological Process | GO:0070221 | sulfide oxidation, using sulfide:quinone oxidoreductase |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.