Search Results
Overview
| Uniprot ID | B0BN18 |
|---|---|
| Protein Name | Prefoldin subunit 2 |
| Gene Name | Pfdn2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 18 | SGGSGTGKGAVSAEQ |
Function
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins
Protein Sequence
10
MADSSGRVGK
20
SGGSGTGKGA
30
VSAEQVIAGF
40
NRLRQEQRGL
50
ASKAAELEME
60
LNEHSLVIDT
70
LKEVDETRKC
80
YRMVGGVLVE
90
RTVKEVLPAL
100
EGNKEQIQKI
110
IETLSQQLQA
120
KGKELNEFRE
130
KHNIRLMGED
140
EKPAAKENSE
150
GAGAKSSSAG
VLVS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0016272 | prefoldin complex |
| Cellular Component | GO:1990062 | RPAP3/R2TP/prefoldin-like complex |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:1905907 | negative regulation of amyloid fibril formation |
| Biological Process | GO:0051495 | positive regulation of cytoskeleton organization |
| Biological Process | GO:0006457 | protein folding |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.