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Overview

Uniprot IDB0BN63
Protein NameActivator of 90 kDa heat shock protein ATPase homolog 1
Gene NameAhsa1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
198 APSKSQAKPVGVKIP
203 QAKPVGVKIPTCKIT
3 *****MAKWGEGDPR

Function

Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins

Protein Sequence

10 MAKWGEGDPR 20 WIVEERADAT 30 NVNNWHWTER 40 DASNWSTEKL 50 KTLFLAVRVE 60 NEEGKCEVTE 70 VNKLDGEASI 80 NNRKGKLIFF 90 YEWTIKLNWT 100 GTSKSGVQYK 110 GHVEIPNLSD 120 ENSVDEVEIS 130 VSLAKDEPDT 140 SLVALMKEDG 150 VKLLREAVGI 160 YISTLKTEFT 170 QGMILPTVNG 180 ESVDPVGQPA 190 LKTEVCKAKC 200 APSKSQAKPV 210 GVKIPTCKIT 220 LKETFLTSPE 230 ELYRVFTTQE 240 LVQAFTHAPA 250 ALEADRGGKF 260 HMVDGNVTGE 270 FTDLVPEKHI 280 AMKWRFKSWP 290 EGHFATITLT 300 FIDKNGETEL 310 CMEGRGIPAP 320 EEERTRQGWQ 330 RYYFEGIKQT FGYGARLF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005783 endoplasmic reticulum
Molecular Function GO:0001671 ATPase activator activity
Molecular Function GO:0051879 Hsp90 protein binding
Molecular Function GO:0044183 protein folding chaperone
Molecular Function GO:0051087 protein-folding chaperone binding
Molecular Function GO:0051082 unfolded protein binding
Biological Process GO:0036506 maintenance of unfolded protein
Biological Process GO:0032781 positive regulation of ATP-dependent activity
Biological Process GO:0006457 protein folding

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.