Overview
| Uniprot ID | B0BN99 |
|---|
| Protein Name | High mobility group protein B3 |
|---|
| Gene Name | Hmgb3 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 170 |
KGKFDGAKGPAKVAR |
Function
Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling
Protein Sequence
10
MAKGDPKKPK
20
GKMSAYAFFV
30
QTCREEHKKK
40
NPEVPVNFAE
50
FSKKCSERWK
60
TMSSKEKSKF
70
DEMAKADKVR
80
YDREMKDYGP
90
AKGGKKKKDP
100
NAPKRPPSGF
110
FLFCSEFRPK
120
IKSANPGISI
130
GDVAKKLGEM
140
WNNLSDSEKQ
150
PYMTKAAKLK
160
EKYEKDVADY
170
KSKGKFDGAK
180
GPAKVARKKV
190
EEEEEEEEEE
200
EEEEEEEEDE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005694 |
chromosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0008301 |
DNA binding, bending |
| Molecular Function |
GO:0000400 |
four-way junction DNA binding |
| Biological Process |
GO:0032392 |
DNA geometric change |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0045087 |
innate immune response |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.