Search Results
Overview
| Uniprot ID | B0BNA5 |
|---|---|
| Protein Name | Coactosin-like protein |
| Gene Name | Cotl1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 118 | EFVISDRKELEEDFI |
| 7 | *MATKIDKEACRAAY |
| 72 | TTGDAMSKRSKFALI |
Function
Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis (By similarity)
Protein Sequence
10
MATKIDKEAC
20
RAAYNLVRDD
30
GSSVIWVTFK
40
YDGATIVPGD
50
QGADYQHFIQ
60
QCTDDVRLFA
70
FVRFTTGDAM
80
SKRSKFALIT
90
WIGEDVSGLQ
100
RAKTGTDKTL
110
VKEVVQNFAK
120
EFVISDRKEL
130
EEDFIRSELK
140
KAGGANYDAQ
SE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030864 | cortical actin cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0030427 | site of polarized growth |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Biological Process | GO:0050832 | defense response to fungus |
| Biological Process | GO:0030833 | regulation of actin filament polymerization |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.