Overview
| Uniprot ID | B0BNB4 |
|---|
| Protein Name | Chromatin modification-related protein MEAF6 |
|---|
| Gene Name | Meaf6 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 182 |
NRHRIDLKLNKKPRA |
Function
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity
Protein Sequence
10
MAMHNKTAPP
20
QIPDTRRELA
30
ELVKRKQELA
40
ETLANLERQI
50
YAFEGSYLED
60
TQMYGNIIRG
70
WDRYLTNQKN
80
SNSKNDRRNR
90
KFKEAERLFS
100
KSSVTSAAAV
110
SALAGVQDQL
120
IEKREPGSGT
130
ESDTSPDFHN
140
QENEPAQEDP
150
EDLDGSVQGV
160
KPQKAASSTS
170
SGSHHSSHKK
180
RKNKNRHRID
190
LKLNKKPRAD
Y
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000776 |
kinetochore |
| Cellular Component |
GO:0070776 |
MOZ/MORF histone acetyltransferase complex |
| Cellular Component |
GO:0035267 |
NuA4 histone acetyltransferase complex |
| Cellular Component |
GO:0005730 |
nucleolus |
| Biological Process |
GO:0006325 |
chromatin organization |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.