Search Results
Overview
| Uniprot ID | B0BND0 |
|---|---|
| Protein Name | Glycerophosphocholine cholinephosphodiesterase ENPP6 |
| Gene Name | Enpp6 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 289 | KHSEIYHKLRTVEHM |
Function
Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Protein Sequence
10
MAGKLWTFLL
20
LFGFSWVWPA
30
SAHRKLLVLL
40
LDGFRSDYIS
50
EDALASLPGF
60
REIVNRGVKV
70
DYLTPDFPSL
80
SYPNYYTLMT
90
GRHCEVHQMI
100
GNYMWDPRTN
110
KSFDIGVNRD
120
SLMPLWWNGS
130
EPLWITLMKA
140
RRKVYMYYWP
150
GCEVEILGVR
160
PTYCLEYKNV
170
PTDINFANAV
180
SDALDSLKSG
190
RADLAAIYHE
200
RIDVEGHHYG
210
PSSPQRKDAL
220
KAVDTVLKYM
230
TQWIQERGLQ
240
NDLNVILFSD
250
HGMTDIFWMD
260
KVIELSKYIS
270
LDDLQQVKDQ
280
GPVVSLWPVP
290
EKHSEIYHKL
300
RTVEHMTVYE
310
KEAIPNRFYY
320
KKGKFVSPLT
330
LVADEGWFIA
340
ESREALPFWM
350
NSTGKREGWQ
360
HGWHGYDNEL
370
MDMRGIFLAF
380
GPDFKSNFRA
390
APIRSVDVYN
400
IMCNVVGITP
410
LPNNGSWSRV
420
VCMLKSQTSS
430
SPSIPPNSCA
440
LVLILLLYFV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098552 | side of membrane |
| Molecular Function | GO:0047390 | glycerophosphocholine cholinephosphodiesterase activity |
| Molecular Function | GO:0008889 | glycerophosphodiester phosphodiesterase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0008081 | phosphoric diester hydrolase activity |
| Biological Process | GO:0019695 | choline metabolic process |
| Biological Process | GO:0016042 | lipid catabolic process |
| Biological Process | GO:0006629 | lipid metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.