Overview
| Uniprot ID | B0BND5 |
|---|
| Protein Name | U3 small nucleolar RNA-interacting protein 2 |
|---|
| Gene Name | Rrp9 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 87 |
EKKLRLAKLYLEQLR |
Function
Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome
Protein Sequence
10
MNSMSTAVAT
20
RKRAKPAPGP
30
GAAPVDGKRR
40
RKVDSAASRG
50
KSKGGGKMNE
60
EISSDSESES
70
LAPRKTEEEE
80
EEELEETAQE
90
KKLRLAKLYL
100
EQLRQQEEEK
110
AEARAFEEDQ
120
VAGRLKEDVL
130
EQRGRLQKLV
140
AKEIQAPAPT
150
DIRVLRGHQL
160
SITCLVITPD
170
DLAIFSAAKD
180
CTIIKWSVET
190
GRKLHVIPRA
200
KKGTQGQPSG
210
HSSHILCMAI
220
SSDGKYLASG
230
DRSKLILIWE
240
AQSCQHLYTF
250
TGHRDAVSGL
260
AFRRGTHQLY
270
STSHDRSVKV
280
WNAAENSYVE
290
TLFGHQDAVA
300
ALDALSRECC
310
VTAGGRDGTV
320
RVWKIPEESQ
330
LVFYGHQGSI
340
DCIHLINEEH
350
MVSGADDGSV
360
ALWGLSKKRP
370
LALQREAHGL
380
HGEPGLEQPF
390
WISSVAALLN
400
TDLVATGSHN
410
ACVRLWQCGE
420
GFRQLDPLCD
430
IPLVGFINSL
440
KFSSGGDFLV
450
AGVGQEHRLG
460
RWWRIKEARN
470
SVCIIPLRRV
PVSPVAGS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031428 |
box C/D methylation guide snoRNP complex |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0032040 |
small-subunit processome |
| Molecular Function |
GO:0030515 |
snoRNA binding |
| Molecular Function |
GO:0034511 |
U3 snoRNA binding |
| Biological Process |
GO:0042274 |
ribosomal small subunit biogenesis |
| Biological Process |
GO:0006364 |
rRNA processing |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.