Search Results
Overview
| Uniprot ID | B0K014 |
|---|---|
| Protein Name | D-aminoacyl-tRNA deacylase |
| Gene Name | Dtd1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 183 | KGPSESSKERNTPRK |
| 61 | VFEDESGKHWSKSVM |
Function
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
Protein Sequence
10
MKAVVQRVTR
20
ASVTVGGEQI
30
SAIGRGICVL
40
LGISMEDTQK
50
ELEHMVRKIL
60
NLRVFEDESG
70
KHWSKSVMDK
80
EYEVLCVSQF
90
TLQCVLKGNK
100
PDLHLAMPTE
110
QAESFYNSFL
120
EQLRKSYRPE
130
LIRDGKFGAY
140
MQVHIQNDGP
150
VTIELESPAP
160
GAASSDPKQL
170
SKLEKQQQRK
180
EKTRAKGPSE
190
SSKERNTPRK
200
EDRSASSGAE
GDVSSEREP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0051500 | D-tyrosyl-tRNA(Tyr) deacylase activity |
| Molecular Function | GO:0000049 | tRNA binding |
| Biological Process | GO:0006399 | tRNA metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.