Search Results

Overview

Uniprot IDB0LPN4
Protein NameRyanodine receptor 2
Gene NameRyr2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1468 TLGDEKGKVHESIKR

Function

Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development

Protein Sequence

10 MADAGEGEDE 20 IQFLRTDDEV 30 VLQCTATIHK 40 EQQKLCLAAE 50 GFGNRLCFLE 60 STSNSKNVPP 70 DLSICTFVLE 80 QSLSVRALQE 90 MLANTVEKSE 100 GKFMMKTAQG 110 GGHRTLLYGH 120 AILLRHSYSG 130 MYLCCLSTSR 140 SSTDKLAFDV 150 GLQEDTTGEA 160 CWWTIHPASK 170 QRSEGEKVRV 180 GDDLILVSVS 190 SERYLHLSYG 200 NSSWRVDAAF 210 QQTLWSVAPI 220 SSGSEAAQGY 230 LIGGDVLRLL 240 HGHMDECLTV 250 PSGEHGEEQR 260 RTVHYEGGAV 270 SVHARSLWRL 280 ETLRVAWSGS 290 HIRWGQPFRL 300 RHVTTGKYLS 310 LMEDKNLLLM 320 DKEKADVKST 330 AFAFRSSKEK 340 LDAGVRKEVD 350 GMGTSEIKYG 360 DSICYIQHVD 370 TGLWLTYQAV 380 DVKSARMGSI 390 QRKAIMHHEG 400 HMDDGLNLSR 410 SQHEESRTAR 420 VIRSTVFLFN 430 RFIRGLDALS 440 KRAKLPTVDL 450 PIESVSLSLQ 460 DLIGYFHPPD 470 EHLEHEDKQN 480 RLRALKNRQN 490 LFQEEGMINL 500 VLECIDRLHV 510 YSSAAHFADV 520 AGREAGESWK 530 SILNSLYELL 540 AALIRGNRKN 550 CAQFSGSLDW 560 LISRLERLEA 570 SSGILEVLHC 580 VLVESPEALN 590 IIKEGHIKSI 600 ISLLDKHGRN 610 HKVLDVLCSL 620 CVCHGVAVRS 630 NQHLICDNLL 640 PGRDLLLQTR 650 LVNHVSSMRP 660 NIFLGVSEGS 670 AQYKKWYYEL 680 MVDHTEPFVT 690 AEATHLRVGW 700 ASTEGYSPYP 710 GGGEEWGGNG 720 VGDDLFSYGF 730 DGLHLWSGCI 740 ARTVSSPNQH 750 LLRTDDVISC 760 CLDLSAPSIS 770 FRINGQPVQG 780 MFENFNIDGL 790 FFPVVSFSAG 800 IKVRFLLGGR 810 HGEFKFLPPP 820 GYAACYEAVL 830 PKEKLKVEHS 840 REYKQERTYT 850 RDLLGPTVSL 860 TQAAFTPVPV 870 DTSQIVLPPH 880 LERIRERLAE 890 NIHELWVMNK 900 IELGWQYGPV 910 RDDNKRQHPC 920 LVEFCKLPEQ 930 ERNYNLQMSL 940 ETLKTLLALG 950 CHVGIADEHA 960 EEKVKKMKLP 970 KNYQLTSGYK 980 PAPMDLSFIK 990 LTPSQEAMVD 1000 KLAENAHNVW 1010 ARDRIRQGWT 1020 YGIQQDVKNR 1030 RNPRLVPYTL 1040 LDDRTKKSNK 1050 DSLREAVRTL 1060 LGYGYHLEAP 1070 DQDHASRAEV 1080 CSGTGERFRI 1090 FRAEKTYAVK 1100 AGRWYFEFEA 1110 VTAGDMRVGW 1120 SRPGCQPDLE 1130 LGSDERAFAF 1140 DGFKAQRWHQ 1150 GNEHYGRSWQ 1160 AGDVVGCMVD 1170 MNEHTMMFTL 1180 NGEILLDDSG 1190 SELAFKDFDV 1200 GDGFIPVCSL 1210 GVAQVGRMNF 1220 GKDVSTLKYF 1230 TICGLQEGYE 1240 PFAVNTNRDI 1250 TMWLSKRLPQ 1260 FLQVPSNHEH 1270 IEVTRIDGTI 1280 DSSPCLKVTQ 1290 KSFGSQNSNT 1300 DIMFYRLSMP 1310 IECAEVFSKS 1320 VAGGIPGAGF 1330 YGPKNDLEDF 1340 DVDSDFEVLM 1350 KTAHGHLVPD 1360 RMDKDKETPK 1370 PEFNNHKDYA 1380 QEKPSRLKQR 1390 FLLRRTKPDY 1400 STSHSARLTE 1410 DVLADDRDDY 1420 EYLMQTSTYY 1430 YSVRIFPGQE 1440 PANVWVGWIT 1450 SDFHQYDTGF 1460 DLDRVRTVTV 1470 TLGDEKGKVH 1480 ESIKRSNCYM 1490 VCAGESMSPG 1500 QGRNNSNGLE 1510 IGCVVDAASG 1520 LLTFIANGKE 1530 LSTYYQVEPS 1540 TKLFPAVFAQ 1550 ATSPNVFQFE 1560 LGRIKNVMPL 1570 SAGLFKSEHK 1580 NPVPQCPPRL 1590 HVQFLSHVLW 1600 SRMPNQFLKV 1610 DVSRISERQG 1620 WLVQCLDPLQ 1630 FMSLHIPEEN 1640 RSVDILELTE 1650 QEELLQFHYH 1660 TLRLYSAVCA 1670 LGNHRVAHAL 1680 CSHVDEPQLL 1690 YAIENKYMPG 1700 LLRAGYYDLL 1710 IDIHLSSYAT 1720 ARLMMNNEFI 1730 VPMTEETKSI 1740 TLFPDENKKH 1750 GLPGIGLSTS 1760 LRPRMCFSSP 1770 SFVSISNECY 1780 QYSPEFPLDI 1790 LKAKTIQMLT 1800 EAVKEGSLHA 1810 RDPVGGTTEF 1820 LFVPLIKLFY 1830 TLLIMGIFHN 1840 EDLKHILQLI 1850 EPSVFKEAAT 1860 PEEEGGAPEK 1870 EISIDDSKLE 1880 VKEEAKAGKR 1890 PKEGLLQMKL 1900 PEPVKLQMCL 1910 LLQYLCDCQV 1920 RHRIEAIVAF 1930 SDDFVAKLQD 1940 NQRFRYNEVM 1950 QALNMSAALT 1960 ARKTKEFRSP 1970 PQEQINMLLN 1980 FKDDKSECPC 1990 PEEIRDQLLD 2000 FHEDLMTHCG 2010 IELDEDGSLD 2020 GSNDLTIRGR 2030 LLSLVEKVTY 2040 LKKKQAEKPV 2050 ASDSRKSSSL 2060 QQLISETMVR 2070 WAQESVIEDP 2080 ELVRAMFVLL 2090 HRQYDGIGGL 2100 VRALPKTYTI 2110 NGVSVEDTIN 2120 LLASLGQIRS 2130 LLSVRMGKEE 2140 EKLMIRGLGD 2150 IMNNKVFYQH 2160 PNLMRALGMH 2170 ETVMEVMVNV 2180 LGGGESKEIT 2190 FPKMVANCCR 2200 FLCYFCRISR 2210 QNQKAMFDHL 2220 SYLLENSSVG 2230 LASPAMRGST 2240 PLDVAAASVM 2250 DNNELALALR 2260 EPDLEKVVRY 2270 LAGCGLQSCQ 2280 MLVSKGYPDI 2290 GWNPVEGERY 2300 LDFLRFAVFC 2310 NGESVEENAN 2320 VVVRLLIRRP 2330 ECFGPALRGE 2340 GGNGLLAAME 2350 EAIKIAEDPS 2360 RDGPSPTSGS 2370 SKTLDAEEEE 2380 DDTIHMGNAI 2390 MTFYAALIDL 2400 LGRCAPEMHL 2410 IHAGKGEAIR 2420 IRSILRSLIP 2430 LGDLVGVISI 2440 AFQMPTIAKD 2450 GKVVEPDMSA 2460 GFCPDHKAAM 2470 VLFLDRVYGI 2480 EVQDFLLHLL 2490 EVGFLPDLRA 2500 AASLDTAALS 2510 ATDMALALNR 2520 YLCTAVLPLL 2530 TRCAPLFAGT 2540 EHHASLIDSL 2550 LHTVYRLSKG 2560 CSLTKAQRDS 2570 IEVCLLSICG 2580 QLRPSMMQHL 2590 LRRLVFDVPL 2600 LNEHAKMPLK 2610 LLTNHYERCW 2620 KYYCLPGGWS 2630 NFGAASEEEL 2640 HLSRKLFWGI 2650 FDALSQKKYE 2660 QELFKLALPC 2670 LSAVAGALPP 2680 DYMESNYVSM 2690 MEKQSSMDSE 2700 GNFNPQPVDT 2710 SNITIPEKLE 2720 YFINKYAEHS 2730 HDKWSMDKLA 2740 NGWIYGEIYS 2750 DSSKIQPLMK 2760 PYKLLSEKEK 2770 EIYRWPIKES 2780 LKTMLAWGWR 2790 IERTREGDSM 2800 ALYNRTRRIS 2810 QTSQVSIDAA 2820 HGYSPRAIDM 2830 SNVTLSRDLH 2840 AMAEMMAENY 2850 HNIWAKKKKM 2860 ELESKGGGNH 2870 PLLVPYDTLT 2880 AKEKAKDREK 2890 AQDIFKFLQI 2900 SGYAVSRGFK 2910 DLDLDTPSIE 2920 KRFAYSFLQQ 2930 LIRYVDEAHQ 2940 YILEFDGGSR 2950 SKGEHFPYEQ 2960 EIKFFAKVVL 2970 PLIDQYFKNH 2980 RLYFLSAASR 2990 PLCTGGHASN 3000 KEKEMVTSLF 3010 CKLGVLVRHR 3020 ISLFGNDATS 3030 IVNCLHILGQ 3040 TLDARTVMKT 3050 GLDSVKSALR 3060 AFLDNAAEDL 3070 EKTMENLKQG 3080 QFTHTRSQPK 3090 GVTQIINYTT 3100 VALLPMLSSL 3110 FEHIGQHQFG 3120 EDLILEDVQV 3130 SCYRILTSLY 3140 ALGTSKSIYV 3150 ERQRSALGEC 3160 LAAFAGAFPI 3170 AFLETHLDKH 3180 NVYSIYNTRS 3190 SRERAALSLP 3200 ANVEDVCPNI 3210 PSLEKLMTEI 3220 IELAESGIRY 3230 TQMPHMMEVV 3240 LPMLCSYMSR 3250 WWEHGPENHP 3260 ERAEMCCTAL 3270 NSEHMNTLLG 3280 NILKIIYNNL 3290 GIDEGAWMKR 3300 LAVFSQPIIN 3310 KVKPQLLKTH 3320 FLPLMEKLKK 3330 KAAMVVSEED 3340 HLKAEARGDM 3350 SEAELLILDE 3360 FTTLARDLYA 3370 FYPLLIRFVD 3380 YNRAKWLKEP 3390 NPEAEELFRM 3400 VAEVFIYWSK 3410 SHNFKREEQN 3420 FVVQNEINNM 3430 SFLITDTKSK 3440 MSKAAISDQE 3450 RKKMKRKGDR 3460 YSMQTSLIVA 3470 ALKRLLPIGL 3480 NICAPGDQEL 3490 IALAKNRFSL 3500 KDTEEEVRDV 3510 IRSNIHLQGK 3520 LEDPAIRWQM 3530 ALYKDLPNRA 3540 EDTSDPERTV 3550 ERVLDIANVL 3560 FHLEQVEHPQ 3570 RSKKAVWHKL 3580 LSKQRKRAVV 3590 ACFRMAPLYN 3600 LPRHRAVNLF 3610 LQGYEKSWIE 3620 TEEHYFEDKL 3630 IEDLAKPGSE 3640 LPEEDEAMKR 3650 VDPLHQLILL 3660 FSRTALTEKC 3670 KLEEDFLYMA 3680 YADIMAKSCH 3690 DEEDDDGEEE 3700 VKSFEVTGSQ 3710 RSKEKEMEKQ 3720 KLLYQQARLH 3730 DRGAAEMVLQ 3740 TFSASKGETG 3750 PMVAATLKLG 3760 IAILNGGNST 3770 VQQKMLDYLK 3780 EKKDVGFFQS 3790 LAGLMQSCSV 3800 LDLNAFERQN 3810 KAEGLGMVTE 3820 EGSGEKVLQD 3830 DEFTCDLFRF 3840 LQLLCEGHNS 3850 DFQNYLRTQT 3860 GNNTTVNIII 3870 STVDYLLRVQ 3880 ESISDFYWYY 3890 SGKDIIDEQG 3900 QRNFSKAIQV 3910 AKQVFNTLTE 3920 YIQGPCTGNQ 3930 QSLAHSRLWD 3940 AVVGFLHVFA 3950 HMQMKLSQDS 3960 SQIELLKELM 3970 DLQKDMVVML 3980 LSMLEGNVVN 3990 GTIGKQMVDM 4000 LVESSNNVEM 4010 ILKFFDMFLK 4020 LKDLTSSDTF 4030 KEYDPDGKGV 4040 ISKRDFHKAM 4050 ESHKHYTQSE 4060 TEFLLSCAET 4070 DENETLDYEE 4080 FVKRFHEPAK 4090 DIGFNVAVLL 4100 TNLSEHMPND 4110 TRLQTFLELA 4120 ESVLNYFQPF 4130 LGRIEIMGSA 4140 KRIERVYFEI 4150 SESSRTQWEK 4160 PQVKESKRQF 4170 IFDVVNEGGE 4180 KEKMELFVNF 4190 CEDTIFEMQL 4200 AAQISESDLN 4210 ERSANKEESE 4220 KERPEEQAPR 4230 MGFFSLLTVQ 4240 SALFALRYNV 4250 LTLVRMLSLK 4260 SLKKQMKRMK 4270 KMTVKDMVSA 4280 FFSSYWSVFV 4290 TLLHFVASVC 4300 RGFFRIVSSL 4310 LLGGSLVEGA 4320 KKIKVAELLA 4330 NMPDPTQDEV 4340 RGDEEEGERK 4350 PLESALPSED 4360 LTDLKELTEE 4370 SDLLSDIFGL 4380 DLKREGGQYK 4390 LIPHNPNAGL 4400 SDLMTNPIPV 4410 PEVQEKFQEQ 4420 KVKEEKEGKE 4430 ETKSEPEKAE 4440 GEDGEKEEKA 4450 KDDKGKQKLR 4460 QLHTHRYGEP 4470 EVPESAFWKK 4480 IIAYQQKLLN 4490 YFARNFYNMR 4500 MLALFVAFAI 4510 NFILLFYKVS 4520 TSSVVEGKEL 4530 PTRTSSDAAK 4540 VTTSLDSSPH 4550 RIIAVHYVLE 4560 ESSGYMEPTL 4570 RILAILHTII 4580 SFFCIIGYYC 4590 LKVPLVIFKR 4600 EKEVARKLEF 4610 DGLYITEQPS 4620 EDDIKGQWDR 4630 LVINTQSFPN 4640 NYWDKFVKRK 4650 VMDKYGEFYG 4660 RDRISELLGM 4670 DKAALDFSDA 4680 REKKKPKKDS 4690 SLSAVLNSID 4700 VKYQMWKLGV 4710 VFTDNSFLYL 4720 AWYMTMSVLG 4730 HYNNFFFAAH 4740 LLDIAMGFKT 4750 LRTILSSVTH 4760 NGKQLVLTVG 4770 LLAVVVYLYT 4780 VVAFNFFRKF 4790 YNKSEDGDTP 4800 DMKCDDMLTC 4810 YMFHMYVGVR 4820 AGGGIGDEIE 4830 DPAGDEYEIY 4840 RIIFDITFFF 4850 FVIVILLAII 4860 QGLIIDAFGE 4870 LRDQQEQVKE 4880 DMETKCFICG 4890 IGNDYFDTVP 4900 HGFETHTLQE 4910 HNLANYLFFL 4920 MYLINKDETE 4930 HTGQESYVWK 4940 MYQERCWEFF 4950 PAGDCFRKQY EDQLN

Gene Ontology

Classification GO ID Description
Biological Process GO:0005513 detection of calcium ion
Biological Process GO:0003143 embryonic heart tube morphogenesis
Biological Process GO:0006874 intracellular calcium ion homeostasis
Biological Process GO:0003220 left ventricular cardiac muscle tissue morphogenesis
Biological Process GO:0071421 manganese ion transmembrane transport
Biological Process GO:0034220 monoatomic ion transmembrane transport
Biological Process GO:0051481 negative regulation of cytosolic calcium ion concentration
Biological Process GO:0010460 positive regulation of heart rate
Biological Process GO:0098735 positive regulation of the force of heart contraction
Biological Process GO:0086029 Purkinje myocyte to ventricular cardiac muscle cell signaling
Biological Process GO:0098910 regulation of atrial cardiac muscle cell action potential
Biological Process GO:0098904 regulation of AV node cell action potential
Biological Process GO:0055117 regulation of cardiac muscle contraction
Biological Process GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
Biological Process GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Biological Process GO:0051480 regulation of cytosolic calcium ion concentration
Biological Process GO:0002027 regulation of heart rate
Biological Process GO:0098907 regulation of SA node cell action potential
Biological Process GO:0098911 regulation of ventricular cardiac muscle cell action potential
Biological Process GO:0051209 release of sequestered calcium ion into cytosol
Biological Process GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Biological Process GO:0031000 response to caffeine
Biological Process GO:0051592 response to calcium ion
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0032026 response to magnesium ion
Biological Process GO:0014850 response to muscle activity
Biological Process GO:0035994 response to muscle stretch
Biological Process GO:0007584 response to nutrient
Biological Process GO:0051775 response to redox state
Biological Process GO:0009410 response to xenobiotic stimulus
Biological Process GO:0070296 sarcoplasmic reticulum calcium ion transport
Biological Process GO:0006941 striated muscle contraction
Biological Process GO:0097050 type B pancreatic cell apoptotic process
Biological Process GO:0086005 ventricular cardiac muscle cell action potential
Cellular Component GO:0031672 A band
Cellular Component GO:0034704 calcium channel complex
Cellular Component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0030017 sarcomere
Cellular Component GO:0016529 sarcoplasmic reticulum
Cellular Component GO:0033017 sarcoplasmic reticulum membrane
Cellular Component GO:0005790 smooth endoplasmic reticulum
Cellular Component GO:0005891 voltage-gated calcium channel complex
Cellular Component GO:0030018 Z disc
Molecular Function GO:0005262 calcium channel activity
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0048763 calcium-induced calcium release activity
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0015278 intracellularly gated calcium channel activity
Molecular Function GO:0034236 protein kinase A catalytic subunit binding
Molecular Function GO:0034237 protein kinase A regulatory subunit binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0005219 ryanodine-sensitive calcium-release channel activity
Molecular Function GO:0097110 scaffold protein binding
Molecular Function GO:0043924 suramin binding
Molecular Function GO:0044325 transmembrane transporter binding
Biological Process GO:0097553 calcium ion transmembrane import into cytosol
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0060402 calcium ion transport into cytosol
Biological Process GO:0019722 calcium-mediated signaling
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0003300 cardiac muscle hypertrophy
Biological Process GO:0071313 cellular response to caffeine
Biological Process GO:0071872 cellular response to epinephrine stimulus

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.