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Overview

Uniprot IDB0LXP5
Protein NameMitogen-activated protein kinase kinase kinase 7
Gene NameTAK1b
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
590 TYYQQCKKQLEVIRS

Function

No function data available.

Protein Sequence

10 MSTASAASSS 20 SSSSAGEMIE 30 APSQVLNFEE 40 IDYKEIEVEE 50 VVGRGAFGVV 60 CKAKWRAKDV 70 AIKQIESESE 80 RKAFIVELRQ 90 LSRVNHPNIV 100 KLYGACLNPV 110 CLVMEYAEGG 120 SLYNVLHGAE 130 PLPYYTAAHA 140 MSWCLQCSQG 150 VAYLHSMQPK 160 ALIHRDLKPP 170 NLLLVAGGTV 180 LKICDFGTAC 190 DIQTHMTNNK 200 GSAAWMAPEV 210 FEGSNYSEKC 220 DVFSWGIILW 230 EVITRRKPFD 240 EIGGPAFRIM 250 WAVHNGTRPP 260 LIKNLPKPIE 270 SLMTRCWSKD 280 PSQRPSMEEI 290 VKIMTHLMRY 300 FPGADEPLQY 310 PCQYSDEGQS 320 NSATSTGSFM 330 DIASTNTSNK 340 SDTNMEQVPA 350 TNDTIKRLES 360 KLLKNQAKQQ 370 SESGRLSLGA 380 SRGSSVESLP 390 PTSEGKRMSA 400 DMSEIEARIA 410 ATTAYSKPKR 420 GHRKTASFGN 430 ILDVPEIVIS 440 GNGQSRRRSI 450 QDLTVTGTEP 460 GQVSSRSSSP 470 SIRMITTSGP 480 TSEKPARSHP 490 WTPDDSTDTN 500 GSDNSIPMAY 510 LTLDHQLQPL 520 APCPNSKESM 530 AVFEQHCKMA 540 QEYMKVQTEI 550 ALLLQRKQEL 560 VAELDQDEKD 570 QQNTSRLVQE 580 HKKLLDENKS 590 LSTYYQQCKK 600 QLEVIRSQQQ KRQGTS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0140672 ATAC complex
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0004707 MAP kinase activity
Molecular Function GO:0004709 MAP kinase kinase kinase activity
Molecular Function GO:0030971 receptor tyrosine kinase binding
Molecular Function GO:0097110 scaffold protein binding
Biological Process GO:0006915 apoptotic process
Biological Process GO:0007249 canonical NF-kappaB signal transduction
Biological Process GO:0071560 cellular response to transforming growth factor beta stimulus
Biological Process GO:0042742 defense response to bacterium
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006955 immune response
Biological Process GO:0006954 inflammatory response
Biological Process GO:0070498 interleukin-1-mediated signaling pathway
Biological Process GO:0038173 interleukin-17A-mediated signaling pathway
Biological Process GO:0038172 interleukin-33-mediated signaling pathway
Biological Process GO:0007254 JNK cascade
Biological Process GO:0038066 p38MAPK cascade
Biological Process GO:0043123 positive regulation of canonical NF-kappaB signal transduction
Biological Process GO:0032743 positive regulation of interleukin-2 production
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction
Biological Process GO:0002726 positive regulation of T cell cytokine production
Biological Process GO:0051403 stress-activated MAPK cascade
Biological Process GO:0034142 toll-like receptor 4 signaling pathway
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:1990450 linear polyubiquitin binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.