Search Results
Overview
| Uniprot ID | B1AR13 |
|---|---|
| Protein Name | CDGSH iron-sulfur domain-containing protein 3, mitochondrial |
| Gene Name | Cisd3 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 130 | HKSEQVQKAEVGSPL |
| 48 | WFPKDPAKPVVAQKT |
| 65 | RLELVAGKTYRWCVC |
| 76 | WCVCGRSKNQPFCDG |
| 96 | RTGLSPLKFKAQETR |
| 98 | GLSPLKFKAQETRTV |
Function
Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function
Protein Sequence
10
MGFRRLSFPT
20
DFIFLFPNHI
30
CLPALSKPYQ
40
RREISSWLAR
50
WFPKDPAKPV
60
VAQKTPIRLE
70
LVAGKTYRWC
80
VCGRSKNQPF
90
CDGSHFFQRT
100
GLSPLKFKAQ
110
ETRTVALCTC
120
KATQRPPYCD
130
GTHKSEQVQK
AEVGSPL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0051604 | protein maturation |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.