Search Results
Overview
| Uniprot ID | B1WC34 |
|---|---|
| Protein Name | Glucosidase 2 subunit beta |
| Gene Name | Prkcsh |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 123 | REKGRKEKESLQQLA |
| 148 | KILIEEWKTAREEKQ |
| 157 | AREEKQSKLLELQAG |
| 165 | LLELQAGKKSLEDQV |
| 166 | LELQAGKKSLEDQVE |
| 195 | EAKDQHRKLWEEQQA |
| 205 | EEQQAAAKARREQEL |
Function
Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia
Protein Sequence
10
MLLLLLLLPL
20
CWAVEVKRPR
30
GVSLSNHHFY
40
DESKPFTCLD
50
GTATIPFDQV
60
NDDYCDCKDG
70
SDEPGTAACP
80
NGSFHCTNTG
90
YKPLYILSSR
100
VNDGVCDCCD
110
GTDEYNSGTV
120
CENTCREKGR
130
KEKESLQQLA
140
EVTREGFRLK
150
KILIEEWKTA
160
REEKQSKLLE
170
LQAGKKSLED
180
QVETLRTAKE
190
EAERPEKEAK
200
DQHRKLWEEQ
210
QAAAKARREQ
220
ELAASAFQEL
230
DDNMDGLVSL
240
AELQTHPELD
250
TDGDGGLSEE
260
EAQALLSGDT
270
QTDTTSFYDR
280
VWAAIRDKYR
290
SEVPPTDIPV
300
PEVTEPKEEK
310
LPVLPPMEEE
320
EEEEEPEEEE
330
EEEEEEEVPP
340
PQQPLRPPSP
350
AEDEKMPPYD
360
EETQAIIDAA
370
QEARNKFEEV
380
ERSLKEMEES
390
IRSLEQEISF
400
DFGPSGEFAY
410
LYSQCYELTT
420
NEYVYRLCPF
430
KLVSQKPKHG
440
GSPTSLGTWG
450
SWAGPDDDKF
460
SAMKYEQGTG
470
CWQGPNRSTT
480
VRLLCGKETV
490
VTSTTEPSRC
500
EYLMELMTPA
510
ACPEPPPEVP
TDGDHDEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0017177 | glucosidase II complex |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005509 | calcium ion binding |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0006491 | N-glycan processing |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.