Search Results
Overview
| Uniprot ID | B1WC37 |
|---|---|
| Protein Name | Mitochondrial tRNA-specific 2-thiouridylase 1 |
| Gene Name | Trmu |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | ISCNKHIKFSCFHHY |
Function
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base
Protein Sequence
10
MSALRHVVCA
20
LSGGVDSAVA
30
ALLLRRRGYQ
40
VTGVFMKNWD
50
SLDEQGICAA
60
DKDCEDAYKV
70
CQILDIPFHQ
80
VSYVKEYWND
90
VFSDFLNEYE
100
KGRTPNPDIS
110
CNKHIKFSCF
120
HHYAVDNLGA
130
DAVATGHYAR
140
TSLEDEEVFE
150
QKHTKRPDGL
160
FRNRFEVRNP
170
VKLLQAADSF
180
KDQTFFLSQV
190
SQDALRRTIF
200
PLGELTKDFV
210
KKIAAENRLH
220
HVLQKKESMG
230
ICFIGKRNLE
240
HFLLQVSVSD
250
VSGGLLWAGA
260
PVVMKPVFQY
270
LQPRPGKFIS
280
IEDNRVLGTH
290
KGWFLYTLGQ
300
RAKISGLSEP
310
WYVVEKDGTK
320
GDVLVAPRVD
330
HPALYRDLLR
340
TNRVHWIAEE
350
PPAALVRDKM
360
MECHFRFRHQ
370
MALVPCVLTL
380
NQDGTVWVTA
390
VKAVRGLALG
400
QFAVFYKGEE
410
CLGSGKILRL
420
GPSAYTLQKG
430
KNRTRVAPEV
440
SSDSPGLHPT
S
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0000049 | tRNA binding |
| Molecular Function | GO:0061708 | tRNA-5-taurinomethyluridine 2-sulfurtransferase activity |
| Biological Process | GO:0002143 | tRNA wobble position uridine thiolation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.