Overview
| Uniprot ID | B1WC67 |
|---|
| Protein Name | Mitochondrial adenyl nucleotide antiporter SLC25A24 |
|---|
| Gene Name | Slc25a24 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 435 |
LFQRIVSKEGVSGLY |
Function
Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenyl nucleotide pool, could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways. In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides. May play a role in protecting cells against oxidative stress-induced cell death, by buffering calcium levels in the mitochondrial matrix through the formation of calcium-phosphate precipitates
Protein Sequence
10
MLRWLRAFVL
20
PTAVCQDAEP
30
PTRYETLFRA
40
LDRNGDGVVD
50
IGELQQGLQS
60
LGIPLGQAAE
70
EKIFTTGDVN
80
KDGKLDFEEF
90
MKYLKDHEKK
100
MKLAFKSLDK
110
NNDGKIEPFE
120
IVQSLQMLGL
130
NISEKQAELI
140
LQSIDSDGTM
150
TVDWNEWRDY
160
FLFNPVTDIE
170
EIIRFWKHST
180
GIDIGDSLTI
190
PDEFTEDEKK
200
SGQWWRQLLA
210
GGVAGAVSRT
220
STAPLDRLKV
230
MMQVHGSKSM
240
NIFGGFRQMV
250
KEGGIRSLWR
260
GNGINVIKIA
270
PETAVKFWAY
280
EQYKKLLTEE
290
GQKLGTSERF
300
ISGSMAGATA
310
QTFIYPMEVL
320
KTRLAVAKTG
330
QYSGIYGCAK
340
KILKHEGFRA
350
FYKGYVPNLL
360
GIIPYAGIDL
370
AVYELLKSYW
380
LDNFAKDSVN
390
PGVVVLLGCG
400
ALSSTCGQLA
410
SYPLALVRTR
420
MQAQATTEGA
430
PQLSMVGLFQ
440
RIVSKEGVSG
450
LYRGITPNFM
460
KVLPAVGISY
470
VVYENMKQTL
GVAQK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Molecular Function |
GO:0140988 |
ADP:phosphate antiporter activity |
| Molecular Function |
GO:0140987 |
ATP:phosphate antiporter activity |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Biological Process |
GO:0071277 |
cellular response to calcium ion |
| Biological Process |
GO:0034599 |
cellular response to oxidative stress |
| Biological Process |
GO:1990544 |
mitochondrial ATP transmembrane transport |
| Biological Process |
GO:0006839 |
mitochondrial transport |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.