Overview
| Uniprot ID | B2DCZ9 |
|---|
| Protein Name | Rho guanine nucleotide exchange factor 2 |
|---|
| Gene Name | ARHGEF2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 310 |
PSADQMRKTYSEFCS |
| 327 |
TKALKLYKELYARDK |
| 367 |
LVTQRITKYPVLISR |
| 412 |
QDVHELEKGARLQEI |
| 61 |
DTLANCTKVKQKQQK |
| 68 |
KVKQKQQKAALLKNN |
| 73 |
QQKAALLKNNTALQS |
Function
Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability. Involved in neuronal progenitor cell division and differentiation. Involved in the migration of precerebellar neurons
Protein Sequence
10
MKEAKDARYT
20
NGHLFTTISV
30
SGMTMCYACN
40
KSITAKEALI
50
CPTCNVTIHN
60
RCKDTLANCT
70
KVKQKQQKAA
80
LLKNNTALQS
90
VSLRSKTTTR
100
ERPSSAIYPS
110
DSFRQSLLGS
120
RRGRSPLSLA
130
KSVSTTNIAG
140
HFNDESPLGL
150
RRILSQSTDS
160
LNMRNRTLSV
170
ESLIDEGAEV
180
IYNELMSDFE
190
MGEKDFAADS
200
WSLAVDSSFL
210
QQHKKEVMKQ
220
QDVIYELIQT
230
ELHHVRTLKI
240
MTRLFRTGML
250
EELQLEPGVV
260
QGLFPCVDEL
270
SDIHTRFLSQ
280
LLERRRQALC
290
PGSPRNFVIH
300
RLGDLLITQF
310
SGPSADQMRK
320
TYSEFCSRHT
330
KALKLYKELY
340
ARDKRFQQFI
350
RKVTRSAVLK
360
RHGVQECILL
370
VTQRITKYPV
380
LISRILQHTH
390
GIEEERQDLT
400
TALGLVKELL
410
SNVDQDVHEL
420
EKGARLQEIY
430
NRMDPRAQTP
440
VPGKGPFGRE
450
ELLRRKLIHD
460
GCLLWKTAAG
470
RFKDVLMLLM
480
TDVLVFLQEK
490
DQKYIFPALD
500
KPSVVSLQNL
510
IVRDIANQEK
520
GMFLISAAPP
530
EMYEVHTASR
540
DDRSTWIRVI
550
QQSVRVCPSR
560
EDFPLIETED
570
EAYLRRIKME
580
LQQKDRALVE
590
LLQEKVGLFA
600
EMTHFQVEED
610
GGGGMPLPTL
620
PRGLFRSESL
630
ESPRGERLLQ
640
DAIREVEGLK
650
DLLVGPGVEL
660
LLTSREPALP
670
VETDSGGNTS
680
PGVTANGEAR
690
TFNGSIELCR
700
ADSDSSQKDR
710
NGNQLRSPQE
720
EALQRLVNLY
730
GLLHGLQAAV
740
AQQDTLMEAR
750
FPEGPERREK
760
LTRANSRDGE
770
AGRAGAAPVA
780
PEKQATELAL
790
LQRQHALLQE
800
ELRRCRRLGE
810
ERATEAGSLE
820
ARLRESEQAR
830
ALLEREVEEA
840
RRQLAALGHT
850
EPLPAEAPWA
860
RRPLDPRRRS
870
LPAGDALYLS
880
FTPPQPSRGH
890
DRLDLPVTIR
900
SVHRPFEDRE
910
RQELGSPDER
920
LQDSSDPDTG
930
SEEEGSSSRL
940
SPPHSPRDFT
950
RMQDIPEETE
960
SRDGEPVASE
S
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005923 |
bicellular tight junction |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0005874 |
microtubule |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Cellular Component |
GO:0032587 |
ruffle membrane |
| Cellular Component |
GO:0005819 |
spindle |
| Cellular Component |
GO:0031982 |
vesicle |
| Molecular Function |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
| Molecular Function |
GO:0008017 |
microtubule binding |
| Molecular Function |
GO:0031267 |
small GTPase binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0007015 |
actin filament organization |
| Biological Process |
GO:0055059 |
asymmetric neuroblast division |
| Biological Process |
GO:0000902 |
cell morphogenesis |
| Biological Process |
GO:0071225 |
cellular response to muramyl dipeptide |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0007026 |
negative regulation of microtubule depolymerization |
| Biological Process |
GO:0045742 |
positive regulation of epidermal growth factor receptor signaling pathway |
| Biological Process |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
| Biological Process |
GO:0032755 |
positive regulation of interleukin-6 production |
| Biological Process |
GO:1904685 |
positive regulation of metalloendopeptidase activity |
| Biological Process |
GO:0045666 |
positive regulation of neuron differentiation |
| Biological Process |
GO:2001224 |
positive regulation of neuron migration |
| Biological Process |
GO:1900745 |
positive regulation of p38MAPK cascade |
| Biological Process |
GO:0035022 |
positive regulation of Rac protein signal transduction |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0032760 |
positive regulation of tumor necrosis factor production |
| Biological Process |
GO:0090303 |
positive regulation of wound healing |
| Biological Process |
GO:0035023 |
regulation of Rho protein signal transduction |
| Biological Process |
GO:0007264 |
small GTPase-mediated signal transduction |
| Biological Process |
GO:0033209 |
tumor necrosis factor-mediated signaling pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.