Search Results

Overview

Uniprot IDB2GUZ3
Protein NameMonofunctional C1-tetrahydrofolate synthase, mitochondrial
Gene NameMthfd1l
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
515 HESTQTDKALYNRLV
919 SLSHEPDKKGVPRDF

Function

May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2

Protein Sequence

10 MSARLPLLLR 20 QLGHQQLPPG 30 PACRLRELCR 40 SGSRSSSSGG 50 GDPEGLRGRR 60 LQDGQAFISH 70 SPGSPEDPGM 80 DSIVRDVIHN 90 SKEVLNLLQE 100 KNPAFKPVLA 110 VIQAGDDHLM 120 QNVNQNLAKE 130 AGLDITHICL 140 PPDSGEDEII 150 DEILKINEDP 160 RVHGLALQIS 170 EDSLCNKVLN 180 ALKPEKDVDG 190 VTDVNLGKLV 200 RGDAPECFVS 210 PLARAAVELI 220 EKSGITLDGK 230 KVLVIGAHGP 240 LEAALQCLFQ 250 RKGSMTMSSP 260 WITPQLQDKL 270 READIVVLGS 280 PKPDEIPAAW 290 IPSGATMLNC 300 FHDFLSGKLR 310 GGSPGVPMNR 320 LIADESVSLL 330 AAALRVQNMV 340 NSGRRWLREQ 350 QHRRWRLHCL 360 KLQPLSPVPS 370 DIEISRGQTP 380 KAVDVLAKEI 390 GLLADEIEIY 400 GKSKAKVRLS 410 LLERLKDQTD 420 GKYVLVAGIT 430 PTPLGEGKST 440 VTIGLVQALT 450 AHLNVNSFAC 460 LRQPSQGPTF 470 GVKGGAAGGG 480 YAQVIPMEEF 490 NLHLTGDIHA 500 ITAANNLLAA 510 AIDTRIFHES 520 TQTDKALYNR 530 LVPLVNGVRK 540 FSEIQLSRLK 550 KLGIHKTDPT 560 ALTEEEVRKF 570 TRLNIDPSTI 580 TWQRVLDTND 590 RFLRKITIGQ 600 GSTEKGYSRQ 610 AQFDIAVASE 620 IMAVLALTDS 630 LADMKERLGR 640 MVVASDKDGQ 650 PVTAEDLGVT 660 GALTVLMKDA 670 IKPNLMQTLE 680 GTPVFVHAGP 690 FANIAHGNSS 700 VLADKIALKL 710 VGEEGFVVTE 720 AGFGADIGME 730 KFFNIKCRAS 740 GLVPNVVVLV 750 ATVRALKMHG 760 GGPSVTAGVP 770 LKKEYTEENI 780 QLVADGCCNL 790 QKQIQIAQLF 800 GVPVVVALNV 810 FKTDTRAEID 820 LVCELAKRAG 830 AFDAVPCYHW 840 SAGGKGSVDL 850 ARAVREAANK 860 RSRFRFLYDV 870 QLPIVAKIRV 880 IAQTVYGAKD 890 IELSPEAQAK 900 IDRYTQQGFG 910 NLPICMAKTH 920 LSLSHEPDKK 930 GVPRDFILPI 940 SDVRASIGAG 950 FIYPLVGMMS 960 TMPGLPTRPC 970 FYDIDLDTET EQVKGLF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004329 formate-tetrahydrofolate ligase activity
Molecular Function GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
Molecular Function GO:0042803 protein homodimerization activity
Biological Process GO:0009257 10-formyltetrahydrofolate biosynthetic process
Biological Process GO:0048702 embryonic neurocranium morphogenesis
Biological Process GO:0048703 embryonic viscerocranium morphogenesis
Biological Process GO:0006760 folic acid-containing compound metabolic process
Biological Process GO:0015943 formate biosynthetic process
Biological Process GO:0015942 formate metabolic process
Biological Process GO:0001843 neural tube closure
Biological Process GO:0035999 tetrahydrofolate interconversion

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.