Overview
| Uniprot ID | B2GV05 |
|---|
| Protein Name | RNA-binding protein 5 |
|---|
| Gene Name | Rbm5 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 542 |
KTAQQIAKDMERWAK |
| 724 |
PPEPKRKKQFDAGTV |
| 787 |
KGAGLGAKGSAYGLS |
Function
Component of the spliceosome A complex. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (By similarity). Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Caspase-2 that induces apoptosis (By similarity)
Protein Sequence
10
MGSDKRVSRT
20
ERSGRYGSII
30
DRDDRDERES
40
RSRRRDSDYK
50
RSSDDRRGDR
60
YDDYRDYDSP
70
ERERERRNSD
80
RSEDGYHSDG
90
DYGEHDYRHD
100
ISDERESKTI
110
MLRGLPITIT
120
ESDIREMMES
130
FEGPQPADVR
140
LMKRKTGVSR
150
GFAFVEFYHL
160
QDATSWMEAN
170
QKKLVIQGKH
180
IAMHYSNPRP
190
KFEDWLCNKC
200
CLNNFRKRLK
210
CFRCGADKFD
220
SEQEVPPGTT
230
ESVQSVDYYC
240
DTIILRNIAP
250
HTVVDSIMTA
260
LSPYASLAVN
270
NIRLIKDKQT
280
QQNRGFAFVQ
290
LSSAMDASQL
300
LQILQSLHPP
310
LKIDGKTIGV
320
DFAKSARKDL
330
VLPDGNRVSA
340
FSVASTAIAA
350
AQWSSTQSQS
360
GEGGNVDYSY
370
MQPGQDGYTQ
380
YTQYSQDYQQ
390
FYQQQTGGLE
400
SDASATSGTT
410
VTTTSAAVVS
420
QSPQLYNQTS
430
NPPGSPTEEA
440
QPSTSTSTQA
450
PAASPTGVVP
460
GTKYAVPDTS
470
TYQYDESSGY
480
YYDPTTGLYY
490
DPNSQYYYNS
500
LTQQYLYWDG
510
EKETYVPAAE
520
SSSNQQAGLP
530
STKEGKEKKE
540
KPKSKTAQQI
550
AKDMERWAKS
560
LNKQKENFKN
570
SFQPVNSLRE
580
EERRESAAAD
590
AGFALFEKKG
600
ALAERQQLIP
610
ELVRNGDEEN
620
PLKRGLVAAY
630
SGDSDNEEEL
640
VERLESEEEK
650
LADWKKMACL
660
LCRRQFPNRD
670
ALVRHQQLSD
680
LHKQNMDIYR
690
RSRLSEQELE
700
ALELREREMK
710
YRDRAAERRE
720
KYGIPEPPEP
730
KRKKQFDAGT
740
VNYEQPTKDG
750
IDHSNIGNKM
760
LQAMGWREGS
770
GLGRKCQGIT
780
APIEAQVRLK
790
GAGLGAKGSA
800
YGLSGADSYK
810
DAVRKAMFAR
FTEME
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005681 |
spliceosomal complex |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0000398 |
mRNA splicing, via spliceosome |
| Biological Process |
GO:0043065 |
positive regulation of apoptotic process |
| Biological Process |
GO:0000381 |
regulation of alternative mRNA splicing, via spliceosome |
| Biological Process |
GO:0000245 |
spliceosomal complex assembly |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.