Search Results
Overview
| Uniprot ID | B2GV15 |
|---|---|
| Protein Name | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex |
| Gene Name | Dbt |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 196 | SEVVGSGKDGRILKE |
| 265 | GFQKAMVKTMSAALK |
Function
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component
Protein Sequence
10
MAAARVLGTW
20
SRNAVRLTCV
30
RYFQTYNNVH
40
ILKPQHVCSV
50
GYPLLKSSQP
60
RHSLRTAAVL
70
QGQVVQFKLS
80
DIGEGIREVT
90
IKEWYVKEGD
100
TVSQFDSICE
110
VQSDKASVTI
120
TSRYDGVIKR
130
LYYNLDDIAY
140
VGKPLIDIET
150
EALKDSEEDV
160
VETPAVAHDE
170
HTHQEIKGQK
180
TLATPAVRRL
190
AMENNIKLSE
200
VVGSGKDGRI
210
LKEDILNFLE
220
KQTGAILPPS
230
PKSEITPPPP
240
QPRDRPFPTP
250
VSKPPVFLGK
260
DRTEPVTGFQ
270
KAMVKTMSAA
280
LKIPHFGYCD
290
EVDLTELVKL
300
REELKPVALA
310
RGIKLSFMPF
320
FLKAASLGLL
330
QFPILNASVD
340
ENCQSITYKA
350
SHNIGIAMDT
360
ERGLIVPNVK
370
NVQVRSVFEI
380
AMELNRLQKL
390
GSLGQLSTTD
400
LTGGTFTLSN
410
IGSIGGTYAK
420
PVILPPEVAI
430
GALGAIKALP
440
RFDQKGDVYK
450
AQIMNVSWSA
460
DHRVIDGATM
470
SRFSNLWKSY
480
LENPAFMLLD
LK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0160157 | branched-chain alpha-ketoacid dehydrogenase complex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0042645 | mitochondrial nucleoid |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0043754 | dihydrolipoamide branched chain acyltransferase activity |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0120552 | branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA |
| Biological Process | GO:0009083 | branched-chain amino acid catabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.