Overview
| Uniprot ID | B2GV73 |
|---|
| Protein Name | Actin-related protein 2/3 complex subunit 3 |
|---|
| Gene Name | Arpc3 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 123 |
IYAKPASKQEDETMR |
| 29 |
LPIRSQFKGPAPRET |
| 61 |
FFKNYEIKNEADRTL |
Function
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)
Protein Sequence
10
MPAYHSSLMD
20
PDTKLIGNMA
30
LLPIRSQFKG
40
PAPRETKDTD
50
IVDEAIYYFK
60
ANVFFKNYEI
70
KNEADRTLIY
80
ITLYISECLK
90
KLQKCNSRSQ
100
GEKEMYTLGI
110
TNFPIPGEPG
120
FPLNAIYAKP
130
ASKQEDETMR
140
AYLQQLRQET
150
GLRLCDKVFD
160
PQNDKPSKWW
170
TCFVKRQFMN
KSLSGPGQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005885 |
Arp2/3 protein complex |
| Cellular Component |
GO:0031252 |
cell leading edge |
| Cellular Component |
GO:0031941 |
filamentous actin |
| Cellular Component |
GO:0061850 |
growth cone leading edge |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003779 |
actin binding |
| Molecular Function |
GO:0005200 |
structural constituent of cytoskeleton |
| Biological Process |
GO:0034314 |
Arp2/3 complex-mediated actin nucleation |
| Biological Process |
GO:1990090 |
cellular response to nerve growth factor stimulus |
| Biological Process |
GO:0030833 |
regulation of actin filament polymerization |
| Biological Process |
GO:1900242 |
regulation of synaptic vesicle endocytosis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.