Overview
| Uniprot ID | B2M1R6 |
|---|
| Protein Name | Heterogeneous nuclear ribonucleoprotein K |
|---|
| Gene Name | Hnrnpk |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 139 |
AGGIIGVKGAKIKEL |
| 381 |
LAGSIIGKGGQRIKQ |
Function
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation
Protein Sequence
10
METEQPEETF
20
PNTETNGEFG
30
KRPAEDMEEE
40
QAFKRSRNTD
50
EMVELRILLQ
60
SKNAGAVIGK
70
GGKNIKALRT
80
DYNASVSVPD
90
SSGPERILSI
100
SADIETIGEI
110
LKKIIPTLEE
120
YQHYKGSDFD
130
CELRLLIHQS
140
LAGGIIGVKG
150
AKIKELRENT
160
QTTIKLFQEC
170
CPHSTDRVVL
180
IGGKPDRVVE
190
CIKIILDLIS
200
ESPIKGRAQP
210
YDPNFYDETY
220
DYGGFTMMFD
230
DRRGRPVGFP
240
MRGRGGFDRM
250
PPGRGGRPMP
260
PSRRDYDDMS
270
PRRGPPPPPP
280
GRGGRGGSRA
290
RNLPLPPPPP
300
PRGGDLMAYD
310
RRGRPGDRYD
320
GMVGFSADET
330
WDSAIDTWSP
340
SEWQMAYEPQ
350
GGSGYDYSYA
360
GGRGSYGDLG
370
GPIITTQVTI
380
PKDLAGSIIG
390
KGGQRIKQIR
400
HESGASIKID
410
EPLEGSEDRI
420
ITITGTQDQI
430
QNAQYLLQNS
440
VKQYADVEGF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0002102 |
podosome |
| Cellular Component |
GO:0005681 |
spliceosomal complex |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0010629 |
negative regulation of gene expression |
| Biological Process |
GO:0042981 |
regulation of apoptotic process |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:0043484 |
regulation of RNA splicing |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
[1] Sung E, Sim H, Cho YC, Lee W, Bae JS et al.. Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells.. J Proteome Res 22(12):3683-3691. 2023 Dec 1. PMID: 37897433.