Search Results
Overview
| Uniprot ID | B2RPK0 |
|---|---|
| Protein Name | High mobility group protein B1-like 1 |
| Gene Name | HMGB1P1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 114 | SEYHPKIKGEHPGLS |
| 12 | DPKKPRGKMSSYAFF |
| 127 | LSIGDVAKKLGEMWN |
| 177 | AAKKGVVKAEKSKKK |
| 59 | MSAKEKGKFEDMAKA |
| 68 | EDMAKADKTHYERQM |
| 82 | MKTYIPPKGETKKKF |
| 86 | IPPKGETKKKFKDPN |
| 87 | PPKGETKKKFKDPNA |
| 88 | PKGETKKKFKDPNAP |
| 90 | GETKKKFKDPNAPKR |
Function
Binds preferentially single-stranded DNA and unwinds double-stranded DNA
Protein Sequence
10
MGKGDPKKPR
20
GKMSSYAFFV
30
QTCREEHKKK
40
HSDASVNFSE
50
FSNKCSERWK
60
TMSAKEKGKF
70
EDMAKADKTH
80
YERQMKTYIP
90
PKGETKKKFK
100
DPNAPKRPPS
110
AFFLFCSEYH
120
PKIKGEHPGL
130
SIGDVAKKLG
140
EMWNNTAADD
150
KQPGEKKAAK
160
LKEKYEKDIA
170
AYQAKGKPEA
180
AKKGVVKAEK
190
SKKKKEEEED
200
EEDEEDEEEE
210
DEEDEEDDDD
E
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000793 | condensed chromosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003684 | damaged DNA binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0048018 | receptor ligand activity |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0048468 | cell development |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0006259 | DNA metabolic process |
| Biological Process | GO:0006955 | immune response |
| Biological Process | GO:0010596 | negative regulation of endothelial cell migration |
| Biological Process | GO:0010508 | positive regulation of autophagy |
| Biological Process | GO:0045597 | positive regulation of cell differentiation |
| Biological Process | GO:0032722 | positive regulation of chemokine production |
| Biological Process | GO:0001938 | positive regulation of endothelial cell proliferation |
| Biological Process | GO:0032732 | positive regulation of interleukin-1 production |
| Biological Process | GO:0032755 | positive regulation of interleukin-6 production |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0051052 | regulation of DNA metabolic process |
| Biological Process | GO:1903706 | regulation of hemopoiesis |
| Biological Process | GO:0050792 | regulation of viral process |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.