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Overview

Uniprot IDB2RYB3
Protein NameSerine/arginine repetitive matrix protein 1
Gene NameSrrm1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
140 QRQIEQEKLASLKKQ
246 TSTSDILKAPKPEPV
29 KKLLKQLKFAECLEK
457 SPAPKPRKVELSESE

Function

Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates

Protein Sequence

10 MDAGFFRGTS 20 AEQDNRFSNK 30 QKKLLKQLKF 40 AECLEKKVDM 50 SKVNLEVIKP 60 WITKRVTEIL 70 GFEDDVVIEF 80 IFNQLEVKNP 90 DSKMMQINLT 100 GFLNGKNARE 110 FMGELWPLLL 120 SAQENIAGIP 130 SAFLELKKEE 140 IKQRQIEQEK 150 LASLKKQDED 160 KDKRDKEEKE 170 SSREKRERSR 180 SPRRRKSRSP 190 SPRRRSSPVR 200 RERKRSHSRS 210 PRHRTKSRSP 220 SPAPEKKEKS 230 PELPEPSVRM 240 KDSSVQEATS 250 TSDILKAPKP 260 EPVPEPKEPS 270 PEKNSKKEKE 280 KTRPRSRSRS 290 KSRSRTRSRS 300 PSHTRPRRRH 310 RSRSRSYSPR 320 RRPSPRRRPS 330 PRRRTPPRRM 340 PPPPRHRRSR 350 SPGRRRRRSS 360 ASLSGSSSSS 370 SSSRSRSPPK 380 KPPKRTSSPP 390 RKTRRLSPSA 400 SPPRRRHRPS 410 SPATPPPKTR 420 HSPTPQQSNR 430 ARKSRVSVSP 440 GRTSGKVTKH 450 KGTEKRESPS 460 PAPKPRKVEL 470 SESEEDKGSK 480 MAAADSVQQR 490 RQYRRQNQQS 500 SSDSGSSSTS 510 EDERPKRSHV 520 KNGEVGRRRR 530 HSPSRSASPS 540 PRKRQKETSP 550 RSRRRRSPSP 560 PPARRRRSPS 570 PAPPPPPPPP 580 PRRRRSPTPP 590 PRRRTPSPPP 600 RRRSPSPRRY 610 SPPIQRRYSP 620 SPPPKRRTAS 630 PPPPPKRRAS 640 PSPPPKRRVS 650 HSPPPKQRSP 660 PVTKRRSPSL 670 SSKHRKGSSP 680 GRSTREARSP 690 QPNKRHSPSP 700 RPRAPQTSSP 710 PPVRRGASAS 720 PQGRQSPSPS 730 TRPIRRVSRT 740 PEPKKIKKAA 750 SPSPQSVRRV 760 SSSRSVSGSP 770 EPTAKKPPAP 780 PSPVQSQSPS 790 TNWSPAAPAK 800 KAKSPTPSPS 810 PARNSDQEGG 820 GKKKKKKKDK 830 KHKKDKKHKK 840 HKKHKKEKAV 850 AVATPAPAAP 860 AAVSAAATPS 870 AQEEPAAAPE 880 PRKETESEAE 890 DDNLDDLERH 900 LREKALRSMR KAQVSPQS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005681 spliceosomal complex
Biological Process GO:0006397 mRNA processing
Biological Process GO:0008380 RNA splicing

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.