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Overview

Uniprot ID	B2RYP4
Protein Name	Sorting nexin-2
Gene Name	Snx2
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
116	IAPRIESKSISAPVI
287	GILRMVNKAADAVNK
442	MVANKPDKIQQAKNE

Function

Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN

Protein Sequence

10 MAAEREPPPL 20 GDVKPTDFEE 30 LEDGEDLFTS 40 TVSTLESSPS 50 SPEPASLPAE 60 DISANSNGSR 70 PVEVTLDDDR 80 EDLFAEATEE 90 VSLDSPEREP 100 IMSSEPSPAV 110 TPITPTTLIA 120 PRIESKSISA 130 PVIFDRSREE 140 IEEEANGDIF 150 DIEIGVSDPE 160 KVGDGMNAYM 170 AYRVTTKTSL 180 SMFSKSEFSV 190 KRRFSDFLGL 200 HSKLASKYLH 210 VGYIVPPAPE 220 KSIVGMTKVK 230 VGKEDSSSTE 240 FVEKRRAALE 250 RYLQRTVKHP 260 TLLQDPDLRQ 270 FLESSELPRA 280 VNTQALSGAG 290 ILRMVNKAAD 300 AVNKMTIKMN 310 ESDAWFEEKQ 320 QQFENLDQQL 330 RKLHASVEAL 340 VCHRKELSAN 350 TAAFAKSAAM 360 LGNSEDHTAL 370 SRALSQLAEV 380 EEKIDQLHQE 390 QAFADFYMFS 400 ELLSDYIRLI 410 AAVKGVFDHR 420 MKCWQKWEDA 430 QITLLKKRET 440 EAKMMVANKP 450 DKIQQAKNEI 460 REWEAKVQQG 470 ERDFEQISKT 480 IRKEVGRFEK 490 ERVKDFKAVI 500 IKYLESLVQT 510 QQQLIKYWEA FLPEAKAIA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0031901	early endosome membrane
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0030905	retromer, tubulation complex
Molecular Function	GO:0005154	epidermal growth factor receptor binding
Molecular Function	GO:0005158	insulin receptor binding
Molecular Function	GO:1990460	leptin receptor binding
Molecular Function	GO:0035091	phosphatidylinositol binding
Molecular Function	GO:0046982	protein heterodimerization activity
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:1990459	transferrin receptor binding
Biological Process	GO:0006886	intracellular protein transport
Biological Process	GO:0072673	lamellipodium morphogenesis
Biological Process	GO:0042147	retrograde transport, endosome to Golgi

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.