Search Results
Overview
| Uniprot ID | B2RYW9 |
|---|---|
| Protein Name | Oxaloacetate tautomerase Fahd2a, mitochondrial |
| Gene Name | Fahd2a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 128 | EQNVRVPKNPIIFSK |
| 202 | DWQMRNGKQWLLGKT |
| 287 | PGVGMFRKPPVFLKK |
Function
Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate. It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition
Protein Sequence
10
MLGSGRRRLL
20
STLLQVQKRP
30
CQPCRNMRLV
40
QFQAPHLEEP
50
HVGLESGIGG
60
GVVDLNTFDP
70
ALPKTMVQFL
80
ERGETALSVA
90
RRALAAQLPL
100
IPRSQVTFLA
110
PVTRPDKVIC
120
VGLNYADHCQ
130
EQNVRVPKNP
140
IIFSKFSSSI
150
VGPYDSIILP
160
PESKEVDWEV
170
EMAVVIGKKG
180
KHIKATDVMA
190
YVAGFTVAHD
200
VSARDWQMRN
210
GKQWLLGKTF
220
DTFCPLGPAL
230
VTKDTIADPH
240
NLKISCRVNG
250
EIVQSSNTNQ
260
MVFKTEDLIA
270
WVSQFVTLYP
280
GDILLTGTPP
290
GVGMFRKPPV
300
FLKKGDEVQC
310
EIEELGVIIN
KVV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0050163 | oxaloacetate tautomerase activity |
| Biological Process | GO:0006107 | oxaloacetate metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.