Overview
| Uniprot ID | B3GQS7 |
|---|
| Protein Name | 60 kDa heat shock protein, mitochondrial |
|---|
| Gene Name | HSPD1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 389 |
TSEYEKGKLNERLAK |
Function
Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein
Protein Sequence
10
MLRLPTVFRQ
20
MRPVSRVLAP
30
HLTRAYAKDV
40
KFGADARALM
50
LQGVDLLADA
60
VAVTMGPKGR
70
TVIIEQSWGS
80
PKVTKDGVTV
90
AKSIDLKDKY
100
KNIGAKLVQD
110
VANNTNEEAG
120
DGTTTATVLA
130
RSIAKEGFEK
140
ISKGANPVEI
150
RRGVMLAVDA
160
VIAELKKQSK
170
PVTTPEEIAQ
180
VATISANGDK
190
EIGNIISDAM
200
KKVGRKGVIT
210
VKDGKTLNDE
220
LEIIEGMKFD
230
RGYISPYFIN
240
TSKGQKCEFQ
250
DAYVLLSEKK
260
ISSIQSIVPA
270
LEIANAHRKP
280
LVIIAEDVDG
290
EALSTLVLNR
300
LKVGLQVVAV
310
KAPGFGDNRK
320
NQLKDMAIAT
330
GGAVFGEEGL
340
TLNLEDVQPH
350
DLGKVGEVIV
360
TKDDAMLLKG
370
KGDKAQIEKR
380
IQEIIEQLDV
390
TTSEYEKGKL
400
NERLAKLSDG
410
VAVLKVGGTS
420
DVEVNEKKDR
430
VTDALNATRA
440
AVEEGIVLGG
450
GCALLRCIPA
460
LDSLTPANED
470
QKIGIEIIKR
480
TLKIPAMTIA
490
KNAGVEGSLI
500
VEKIMQSSSE
510
VGYDAMAGDF
520
VNMVEKGIID
530
PTKVVRTALL
540
DAAGVASLLT
550
TAEVVVTEIP
560
KEEKDPGMGA
MGGMGGGMF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0140662 |
ATP-dependent protein folding chaperone |
| Molecular Function |
GO:0016853 |
isomerase activity |
| Biological Process |
GO:0001819 |
positive regulation of cytokine production |
| Biological Process |
GO:0042026 |
protein refolding |
| Biological Process |
GO:0009409 |
response to cold |
Reference
PMID: N/A