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Overview

Uniprot ID	B3SI06
Protein Name	Sodium/potassium-transporting ATPase subunit alpha
Gene Name	atp1a1
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
9	GKGVGRDKYEPAAVS

Function

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis

Protein Sequence

10 MGKGVGRDKY 20 EPAAVSEQGD 30 KKSRKAKKDR 40 DMDELKKEVS 50 MDDHKLSLDE 60 LHRKYGTDLS 70 RGLTSARAAE 80 ILARDGPNSL 90 TPPPTTPEWV 100 KFCRQLFGGF 110 SMLLWIGAIL 120 CFLAYGIESL 130 SMEEGPSNDN 140 LYLGVVLSAV 150 VIITGCFSYY 160 QEAKSSKIMD 170 SFKNMVPQQA 180 LVIRNGEKMS 190 INAEDVVVGD 200 LVEVKGGDRI 210 PADLRIISAN 220 GCKVDNSSLT 230 GESEPQTRSP 240 DFTNENPLET 250 RNIAFFSTNC 260 VEGTARGIVV 270 YTGDRTVMGR 280 IATLASGLEG 290 GQTPIAAEIE 300 HFIHIITGVA 310 VFLGVSFFIL 320 SLILEYTWLE 330 AVIFLIGIIV 340 ANVPEGLLAT 350 VTVCLTLTAK 360 RMARKNCLVK 370 NLEAVETLGS 380 TSTICSDKTG 390 TLTQNRMTVA 400 HMWFDNQIHE 410 ADTTENQSGV 420 SFDKTSATWL 430 ALSRIAGLCN 440 RAVFQANQEN 450 VPILKRAVAG 460 DASESALLKC 470 IELCCGSVNE 480 MRDRYAKIVE 490 IPFNSTNKYQ 500 LSIHKNPNTN 510 EPRHLLVMKG 520 APERILDRCS 530 SILLHGKEQP 540 LDEELKDAFQ 550 NAYLELGGLG 560 ERVLGFCHLL 570 LPDEQFPEGF 580 QFDTDEVNFP 590 LDNLCFVGLI 600 SMIDPPRAAV 610 PDAVGKCRSA 620 GIKVIMVTGD 630 HPITAKAIAK 640 GVGIISEGNE 650 TVEDIAARLN 660 IPVSQVNPRD 670 AKACVLHGSD 680 LKDMTSEQLD 690 DILKHHTEIV 700 FARTSPQQKL 710 IIVEGCQRQG 720 AIVAVTGDGV 730 NDSPALKKAD 740 IGVAMGIAGS 750 DVSKQAADMI 760 LLDDNFASIV 770 TGVEEGRLIF 780 DNLKKSIAYT 790 LTSNIPEITP 800 FLIFIIANIP 810 LPLGTVTILC 820 IDLGTDMVPA 830 ISLAYEQAES 840 DIMKRQPRNP 850 KTDKLVNERL 860 ISMAYGQIGM 870 IQALGGFFTY 880 FVILAENGFL 890 PIHLLGLRVD 900 WDDRWINDME 910 DSYGQQWTYE 920 QRKIVEFTCH 930 TAFFVSIVVV 940 QWADLIICKT 950 RRNSVFQQGM 960 KNKILIFGLF 970 EETALAAFLS 980 YCPGMGVALR 990 MYPLKPTWWF 1000 CAFPYSLLIF 1010 VYDEVRKLII 1020 RRRPGGWVEK ETYY

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016323	basolateral plasma membrane
Cellular Component	GO:0042383	sarcolemma
Cellular Component	GO:0005890	sodium:potassium-exchanging ATPase complex
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0005391	P-type sodium:potassium-exchanging transporter activity
Biological Process	GO:0030007	intracellular potassium ion homeostasis
Biological Process	GO:0006883	intracellular sodium ion homeostasis
Biological Process	GO:1990573	potassium ion import across plasma membrane
Biological Process	GO:1902600	proton transmembrane transport
Biological Process	GO:0036376	sodium ion export across plasma membrane

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.