Search Results
Overview
| Uniprot ID | B4DEE8 |
|---|---|
| Protein Name | Methylated-DNA--protein-cysteine methyltransferase |
| Gene Name | - |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 49 | TLDSPLGKLELSGCE |
Function
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated
Protein Sequence
10
MLGQPAPLER
20
FASRRPQVLA
30
VRTVCDLVLG
40
KMDKDCEMKR
50
TTLDSPLGKL
60
ELSGCEQGLH
70
EIKLLGKGTS
80
AADAVEVPAP
90
AAVLGGPEPL
100
MQCTAWLNAY
110
FHQPEAIEEF
120
PVPALHHPVF
130
QQESFTRQVL
140
WKLLKVVKFG
150
EVISYQQLAA
160
LAGNPKAARA
170
VGGAMRGNPV
180
PILIPCHRVV
190
CSSGAVGNYS
200
GGLAVKEWLL
210
AHEGHRLGKP
220
GLGGSSGLAG
230
AWLKGAGATS
GSPPAGRN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0003908 | methylated-DNA-[protein]-cysteine S-methyltransferase activity |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0032259 | methylation |
Reference
PMID: N/A