Overview
| Uniprot ID | B4DPQ0 |
|---|
| Protein Name | Complement C1r subcomponent |
|---|
| Gene Name | - |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 91 |
GCFYDYVKISADKKS |
Function
Serine protease component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1R catalyzes the first enzymatic step in the classical complement pathway: it is activated by the C1Q subcomplex of the C1 complex, which associates with IgG or IgM immunoglobulins complexed with antigens to form antigen-antibody complexes on the surface of pathogens. Immunoglobulin-binding promotes the autocatalytic cleavage and activation of C1R. Activated C1R then cleaves and activates C1S, the second protease of the classical complement pathway. It is unclear if C1R activates C1S within single, strained C1 complexes or between neighboring C1 complexes on surfaces
Protein Sequence
10
MSVRFRVGRE
20
ENAQWWLLYL
30
LVPALFCRAG
40
GSIPIPQKLF
50
GEVTSPLFPK
60
PYPNNFETTT
70
VITVPTGYRV
80
KLVFQQFDLE
90
PSEGCFYDYV
100
KISADKKSLG
110
RFCGQLGSPL
120
GNPPGKKEFM
130
SQGNKMLLTF
140
HTDFSNEENG
150
TIMFYKGFLA
160
YYQAVDLDEC
170
ASRSKSGEED
180
PQPQCQHLCH
190
NYVGGYFCSC
200
RPGYELQEDR
210
HSCQAECSSE
220
LYTEASGYIS
230
SLEYPRSYPP
240
DLRCNYSIRV
250
ERGLTLHLKF
260
LEPFDIDDHQ
270
QVHCPYDQLQ
280
IYANGKNIGE
290
FCGKQRPPDL
300
DTSSNAVDLL
310
FFTDESGDSR
320
GWKLRYTTEI
330
IKCPQPKTLD
340
EFTIIQNLQP
350
QYQFRDYFIA
360
TCKQGYQLIE
370
GNQVLHSFTA
380
VCQDDGTWHR
390
AMPRCKIKDC
400
GQPRNLPNGD
410
FRYTTTMGVN
420
TYKARIQYYC
430
HEPYYKMQTR
440
AGSRESEQGV
450
YTCTAQGIWK
460
NEQKGEKIPR
470
CLPVCGKPVN
480
PVEQRQRIIG
490
GQKAKMGNFP
500
WQVFTNIHGR
510
GGGALLGDRW
520
ILTAAHTLYP
530
KEHEAQSNAS
540
LDVFLGHTNV
550
EELMKLGNHP
560
IRRVSVHPDY
570
RQDESYNFEG
580
DIALLELENS
590
VTLGPNLLPI
600
CLPDNDTFYD
610
LGLMGYVSGF
620
GVMEEKIAHD
630
LRFVRLPVAN
640
PQACENWLRG
650
KNRMDVFSQN
660
MFCAGHPSLK
670
QDACQGDSGG
680
VFAVRDPNTD
690
RWVATGIVSW
700
GIGCSRGYGF
710
YTKVLNYVDW
IKKEMEEED
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0005615 |
extracellular space |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0004252 |
serine-type endopeptidase activity |
| Biological Process |
GO:0006958 |
complement activation, classical pathway |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0031638 |
zymogen activation |
Reference
PMID: N/A