Search Results
Overview
| Uniprot ID | B4DY08 |
|---|---|
| Protein Name | - |
| Gene Name | - |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 50 | IVGCSVHKGFAFVQY |
Function
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing
Protein Sequence
10
MASNVTNKTD
20
PRSMNSRVFI
30
GNLNTLVVKK
40
SDVEAIFSKY
50
GKIVGCSVHK
60
GFAFVQYVNE
70
RNARAAVAGE
80
DGRMIAGQVL
90
DINLAAEPKV
100
NRGKAGVKRS
110
AAEMYGSSFD
120
LDYDFQRDYY
130
DRMYSYPARV
140
PPPPPIARAV
150
VPSKRQRVSG
160
NTSRRGKSGF
170
NSKSGQRGSS
180
KSGKLKGDDL
190
QAIKKELTQI
200
KQKVDSLLEN
210
LEKIEKEQSK
220
QAVEMKNDKS
230
EEEQSSSSVK
240
KDETNVKMES
250
EGGADDSAEE
260
GDLLDDDDNE
270
DRGDDQVKTT
280
GKERKRWWRG
AQGHMECL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Molecular Function | GO:0003723 | RNA binding |
Reference
PMID: N/A