Search Results
Overview
| Uniprot ID | B4F778 |
|---|---|
| Protein Name | Replication factor C subunit 4 |
| Gene Name | Rfc4 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 18 | STKPQLTKERGISSS |
Function
Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. The RFC4 subunit probably functions as a scaffold on which the other complex components can assemble
Protein Sequence
10
MQAFLKGTSV
20
STKPQLTKER
30
GISSSAGSSG
40
ETKKVKPVPW
50
VEKYRPKCVD
60
EVAFQEEVVA
70
VLKKSLEGAD
80
LPNLLFYGPP
90
GTGKTSTILA
100
AARELFGPEL
110
FRLRVLELNA
120
SDERGIQVVR
130
EKVKNFAQLT
140
VSGSRSDGKP
150
CPPFKIVILD
160
EADSMTSAAQ
170
AALRRTMEKE
180
SKTTRFCLIC
190
NYVSRIIEPL
200
TSRCSKFRFK
210
PLSDKIQQKR
220
LLDIAEKENV
230
KIGDEEIAYL
240
VRISEGDLRK
250
AITFLQSATR
260
LTGGKEISED
270
VITDIAGVIP
280
AATIEGIVTA
290
CHSGSFDKLE
300
AVLKNLIDEG
310
HAATQLVNQL
320
HDSIIEDENL
330
SDKQKSIITE
340
KLAEVDKCLA
350
DGADEHLQLM
360
SLCATVMQQL
TQNC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031390 | Ctf18 RFC-like complex |
| Cellular Component | GO:0005663 | DNA replication factor C complex |
| Cellular Component | GO:0031391 | Elg1 RFC-like complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0031389 | Rad17 RFC-like complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003689 | DNA clamp loader activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0017116 | single-stranded DNA helicase activity |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006261 | DNA-templated DNA replication |
| Biological Process | GO:1900264 | positive regulation of DNA-directed DNA polymerase activity |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.