Overview
| Uniprot ID | B5APU8 |
|---|
| Protein Name | Actin-related protein 2/3 complex subunit 3 |
|---|
| Gene Name | - |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 147 |
TGLRLCEKVFDPQND |
| 155 |
VFDPQNDKPSKWWTC |
| 29 |
LPIRSQFKGPAPRET |
| 56 |
FKANVFFKNYEIKNE |
| 61 |
FFKNYEIKNEADRTL |
Function
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)
Protein Sequence
10
MPAYHSSLMD
20
PDTKLIGNMA
30
LLPIRSQFKG
40
PAPRETKDTD
50
IVDEAIYYFK
60
ANVFFKNYEI
70
KNEADRTLIY
80
ITLYISECLK
90
KLQKCNSKSQ
100
GEKEMYTLGI
110
TNFPIPGEPG
120
FPLNAIYAKP
130
ANKQEDEVMR
140
AYLQQLRQET
150
GLRLCEKVFD
160
PQNDKPSKWW
170
TCFVKRQFMN
KSLSGPGQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005885 |
Arp2/3 protein complex |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0051015 |
actin filament binding |
| Molecular Function |
GO:0005200 |
structural constituent of cytoskeleton |
| Biological Process |
GO:0034314 |
Arp2/3 complex-mediated actin nucleation |
| Biological Process |
GO:0030833 |
regulation of actin filament polymerization |
| Biological Process |
GO:1900242 |
regulation of synaptic vesicle endocytosis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.