Search Results
Overview
| Uniprot ID | B5BU82 |
|---|---|
| Protein Name | Suppressor of cytokine signaling 2 |
| Gene Name | SOCS2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 173 | LCRLTINKCTGAIWG |
Function
Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2. The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR
Protein Sequence
10
MTLRCLEPSG
20
NGGEGTRSQW
30
GTAGSAEEPP
40
PQAARLAKAL
50
RELGQTGWYW
60
GSMTVNEAKE
70
KLKEAPEGTF
80
LIRDSSHSDY
90
LLTISVKTSA
100
GPTNLRIEYQ
110
DGKFRLDSII
120
CVKSKLKQFD
130
SVVHLIDYYV
140
QMCKDKRTGP
150
EAPRNGTVHL
160
YLTKPLYTSA
170
PSLQHLCRLT
180
INKCTGAIWG
190
LPLPTRLKDY
LEEYKFQV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0009968 | negative regulation of signal transduction |
| Biological Process | GO:0016567 | protein ubiquitination |
Reference
PMID: N/A