Search Results

Overview

Uniprot ID	B5DEP7
Protein Name	Small nuclear ribonucleoprotein G
Gene Name	Snrpg
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
3	*****MSKAHPPELK

Function

Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing

Protein Sequence

10 MSKAHPPELK 20 KFMDKKLSLK 30 LNGGRHVQGI 40 LRGFDPFMNL 50 VIDECVEMAT 60 SGQQNNIGMV 70 VIRGNSIIML EALERV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0071013	catalytic step 2 spliceosome
Cellular Component	GO:0005682	U5 snRNP
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0000398	mRNA splicing, via spliceosome
Biological Process	GO:0000387	spliceosomal snRNP assembly
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0043186	P granule
Cellular Component	GO:0071011	precatalytic spliceosome
Cellular Component	GO:0034719	SMN-Sm protein complex
Cellular Component	GO:0097526	spliceosomal tri-snRNP complex
Cellular Component	GO:0005685	U1 snRNP
Cellular Component	GO:0005689	U12-type spliceosomal complex
Cellular Component	GO:0005686	U2 snRNP
Cellular Component	GO:0071004	U2-type prespliceosome
Cellular Component	GO:0005687	U4 snRNP

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.