Search Results

Overview

Uniprot ID	B5DF55
Protein Name	-
Gene Name	Stam
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
162	ASPALVAKDPGTVAT

Function

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes

Protein Sequence

10 MPLFATNPFD 20 QDVEKATSEL 30 NTAEDWGLIL 40 DICDKVGQSR 50 TGPKDCLRSI 60 MRRVNHKDPH 70 VAMQALTLLG 80 ACVSNCGKIF 90 HLEVCSRDFA 100 SEVSNVLNKG 110 HPKVCEKLKA 120 LMVEWTDEFK 130 NDPQLSLISA 140 MIKNLKEQGV 150 TFPAIGSQAA 160 EQAKASPALV 170 AKDPGTVATK 180 KEEEDLAKAI 190 ELSLKEQRQQ 200 AAPLSTLYPS 210 TSSLLTNHQH 220 EGRKVRAVYD 230 FEAAEDNELT 240 FKAGEVITVL 250 DDSDPNWWKG 260 ETHQGMGLFP 270 SNFVTADLTA 280 EPEMIKTEKK 290 TVQFSDDVQI 300 ETIEPEPEPE 310 PAFIDEDKMD 320 QLLQMLQSTD 330 PSDNQPDLPE 340 LLHLEAMCHQ 350 MGPLIDEKLE 360 DIDRKHSELS 370 ELNVKVMEAL 380 SLYTKLMNED 390 PVYSVYAKSQ 400 SQQYYVQASG 410 VSAPQVYPGP 420 AQSGAYLVAG 430 NAQMTHLQSY 440 SLPPEQLASI 450 SQGAVPPSAT 460 PALPNQQAQA 470 SYPNAMVSSV 480 QGNSYPSQAS 490 IYSPAAAAAA 500 VAVTAVPVPA 510 DVTIYQNPGP 520 NMSQVPNYTL 530 TSSTLPHTGG 540 SQQPPQPQQA YSQKALL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0031901	early endosome membrane
Cellular Component	GO:0033565	ESCRT-0 complex
Molecular Function	GO:0035091	phosphatidylinositol binding
Molecular Function	GO:0043130	ubiquitin binding
Molecular Function	GO:0044389	ubiquitin-like protein ligase binding
Biological Process	GO:0016236	macroautophagy
Biological Process	GO:0036258	multivesicular body assembly
Biological Process	GO:1903543	positive regulation of exosomal secretion
Biological Process	GO:0043328	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Biological Process	GO:1903551	regulation of extracellular exosome assembly

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.