Search Results

Overview

Uniprot IDB5DFC8
Protein NameEukaryotic translation initiation factor 3 subunit C
Gene NameEif3c
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
253 KQTVLASKFLKKAPT
318 EKPKMFAKGTEITHA
329 ITHAVVIKKLNEILQ
740 EHVVAASKAMKMGDW
892 DQKDGYRKNEGYMRR
99 KAKSIVDKEGVPRFY

Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression

Protein Sequence

10 MSRFFTTGSD 20 SESESSLSGE 30 ELVTKPVSGN 40 YGKQPLLLSE 50 DEEDTKRVVR 60 SAKDKRFEEL 70 TNLIRTIRNA 80 MKIRDVTKCL 90 EEFELLGKAY 100 GKAKSIVDKE 110 GVPRFYVRIL 120 ADLEDYLNEL 130 WEDKEGKKKM 140 NKNNAKALST 150 LRQKIRKYNR 160 DFESHITNYK 170 QNPEQSADED 180 AEKNEEDSEG 190 SSDEDEDDDG 200 VSGTAFLKKK 210 PDSSGESRKF 220 HKKMEDDDED 230 SEDSEDEEWD 240 TSSTSSDSDS 250 EEEEGKQTVL 260 ASKFLKKAPT 270 TEEDKKAAEK 280 KREDKAKKKH 290 DRKSKRMDEE 300 EEDNEGGEWE 310 RVRGGVPLVK 320 EKPKMFAKGT 330 EITHAVVIKK 340 LNEILQVRGK 350 KGTDRATQIE 360 LLQLLVQIAS 370 ENNLGVGVIV 380 KIKFNIIASL 390 YDYNPNLATY 400 MKPEMWQMCL 410 DCINELMDTL 420 VAHSNIFVGE 430 NILEESENLH 440 NFDQPLRVRG 450 CILTLVERMD 460 EEFTKIMQNT 470 DPHSQEYVEH 480 LKDEAQVCAI 490 IERVQRYLEE 500 KGTTEEICQI 510 YLRRILHTYY 520 KFDYKAHQRQ 530 LTPPEGSSKS 540 EQDQAENEGE 550 DSAVLMERLC 560 KYIYAKDRTD 570 RIRTCAILCH 580 IYHHALHSRW 590 YQARDLMLMS 600 HLQDNIQHAD 610 PPVQILYNRT 620 MVQLGICAFR 630 QGLTKDAHNA 640 LLDIQSSGRA 650 KELLGQGLLL 660 RSLQERNQEQ 670 EKVERRRQVP 680 FHLHINLELL 690 ECVYLVSAML 700 LEIPYMAAHE 710 SDARRRMISK 720 QFHHQLRVGE 730 RQPLLGPPES 740 MREHVVAASK 750 AMKMGDWKTC 760 HSFIINEKMN 770 GKVWDLFPEA 780 DKVRTMLVRK 790 IQEESLRTYL 800 FTYSSVYDSI 810 SMETLSDMFE 820 LDLPTVHSII 830 SKMIINEELM 840 ASLDQPTQTV 850 VMHRTEPTAQ 860 QNLALQLAEK 870 LGSLVENNER 880 VFDHKQGTYG 890 GYFRDQKDGY 900 RKNEGYMRRG 910 GYRQQQSQTA Y

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016282 eukaryotic 43S preinitiation complex
Cellular Component GO:0033290 eukaryotic 48S preinitiation complex
Cellular Component GO:0005852 eukaryotic translation initiation factor 3 complex
Cellular Component GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m
Molecular Function GO:0043022 ribosome binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003743 translation initiation factor activity
Molecular Function GO:0031369 translation initiation factor binding
Biological Process GO:0001732 formation of cytoplasmic translation initiation complex
Biological Process GO:0045727 positive regulation of translation
Biological Process GO:0006413 translational initiation

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.