Search Results
Overview
| Uniprot ID | B5DFF9 |
|---|---|
| Protein Name | E3 SUMO-protein ligase PIAS4 |
| Gene Name | Pias4 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 118 | GLGRLPTKALKPEVR |
Function
No function data available.
Protein Sequence
10
MAAELVEAKN
20
MVMSFRVSDL
30
QMLLGFVGRS
40
KSGLKHELVT
50
RALQLVQFDC
60
SPELFKKIKE
70
LYETRYAKKS
80
AEPGPQAPRP
90
LDPLALHSMP
100
RTPLSGPTVD
110
YPVLYGKYLN
120
GLGRLPTKAL
130
KPEVRLVKLP
140
FFNMLDELLK
150
PTELVPQSAE
160
KLQESPCIFA
170
LTPRQVEMIR
180
NSRELQPGVK
190
AVQVVLRICY
200
SDTSCPQEDQ
210
YPPNIAVKVN
220
HSYCSVPGYY
230
PSNKPGVEPK
240
RPCRPINLTH
250
LMYLSSATNR
260
ITVTWGNYGK
270
SYSVALYLVR
280
QLTSSDLLQR
290
LKTIGVKHPE
300
LCKALVKEKL
310
RLDPDSEIAT
320
TGVRVSLICP
330
LVKMRLSVPC
340
RAETCAHLQC
350
FDAVFYLQMN
360
EKKPTWMCPV
370
CDKPAAYDQL
380
IIDGLLSKIL
390
SECEDADEIE
400
FLAEGSWRPI
410
RAEKEPSCSP
420
QGPILVLGTS
430
DANGLAPASS
440
TPGMGSGLSG
450
PGGAGGGAGA
460
AGGLENGKTG
470
ADVVDLTLDS
480
SSSSEDEDED
490
EDDDEDDDEG
500
PRPKRRCPFQ
KGLVPAC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990234 | transferase complex |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0061665 | SUMO ligase activity |
| Molecular Function | GO:0019789 | SUMO transferase activity |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0001942 | hair follicle development |
| Biological Process | GO:0060887 | limb epidermis development |
| Biological Process | GO:0043124 | negative regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0120186 | negative regulation of protein localization to chromatin |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway |
| Biological Process | GO:1905168 | positive regulation of double-strand break repair via homologous recombination |
| Biological Process | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| Biological Process | GO:1902174 | positive regulation of keratinocyte apoptotic process |
| Biological Process | GO:0033235 | positive regulation of protein sumoylation |
| Biological Process | GO:0016925 | protein sumoylation |
| Biological Process | GO:0043488 | regulation of mRNA stability |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.