Search Results
Overview
| Uniprot ID | B5DFK6 |
|---|---|
| Protein Name | AP-3 complex subunit delta-1 |
| Gene Name | Ap3d1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 165 | TKPYIRKKAVLIMYK |
| 7 | *MALKMVKGSIDRMF |
| 816 | SEKLPVQKHRNAETV |
Function
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals
Protein Sequence
10
MALKMVKGSI
20
DRMFDKNLQD
30
LVRGIRNHKE
40
DEAKYISQCI
50
DEIKQELKQD
60
NIAVKANAVC
70
KLTYLQMLGY
80
DISWAAFNII
90
EVMSASKFTF
100
KRVGYLAASQ
110
CFHEGTDVIM
120
LTTNQIRKDL
130
SSPSQYDTGV
140
ALTGLSCFVT
150
PDLARDLAND
160
IMTLMSHTKP
170
YIRKKAVLIM
180
YKVFLKYPES
190
LRPAFPRLKE
200
KLEDPDPGVQ
210
SAAVNVICEL
220
ARRNPKNYLS
230
LAPLFFKLMT
240
SSTNNWVLIK
250
IIKLFGALTP
260
LEPRLGKKLI
270
EPLTNLIHST
280
SAMSLLYECV
290
NTVIAVLISL
300
SSGMPNHSAS
310
IQLCVQKLRI
320
LIEDSDQNLK
330
YLGLLAMSKI
340
LKTHPKSVQS
350
HKDLILQCLD
360
DKDESIRLRA
370
LDLLYGMVSK
380
KNLMEIVKKL
390
MTHVDKAEGT
400
TYRDELLTKI
410
IDICSQSNYQ
420
HITNFEWYIS
430
ILVELTRLEG
440
TRHGHLIAAQ
450
MLDVAIRVKA
460
IRKFAVSQMS
470
SLLDSAHLVA
480
SSTQRNGICE
490
VLYAAAWICG
500
EFSEHLQGPQ
510
QTLEAMLRPK
520
VTTLPGHIQA
530
VYVQNVVKLY
540
ASILQQKEQA
550
ADTEGAQEVT
560
QLLVERLPQF
570
VQSADLEVQE
580
RASCILQLVK
590
HVQKLQAKGV
600
PVAEEVSALF
610
AGELNPVAPK
620
AQKKVPVPEG
630
LDLDAWINEP
640
PSDSESEDEK
650
PKAIFHEEEP
660
RHTRRRQPEE
670
DEEELARRRE
680
ARKQEQANNP
690
FYIKSSPSPQ
700
KRYQDAPGVE
710
HIPVVQIDLS
720
VPLKVPGMPM
730
SDQYVKLEEQ
740
RRHRQRLEKD
750
KKRKKKEKGK
760
RRHSSLPTES
770
DEDIAPAQRV
780
DIITEEMPEN
790
ALPSDEDDKD
800
PNDPYRALDI
810
DLDKPLADSE
820
KLPVQKHRNA
830
ETVKSPEKEG
840
VPGVEKKSKK
850
PKKKEKKPKE
860
REREKKDKKG
870
EDLDFWLSTT
880
PPPAAAPVPA
890
PSTEGLAASI
900
VTPPKGECEV
910
LKGEEPQDEE
920
DHMDHDQERK
930
SSRHKKKKHR
940
KEKEERPRDK
950
KKAKRKQVVQ
960
LENGAPAEEE
970
EEEEEPIPPM
980
SSYCLLAENP
990
YIKVTYDVQA
1000
SLQKDSQVTV
1010
SIILENQSSS
1020
FLKNMELNVL
1030
DSLNTKMARP
1040
EGSSVHDGVP
1050
VPFQLPPGVS
1060
NEAQFVFTIQ
1070
SIVMAQKLKG
1080
TLSFIAKDDE
1090
GATHEKLDFR
1100
LHFSCSSYLI
1110
TTPCYSDAFA
1120
KLLESGDLSM
1130
NSIKVDGISI
1140
SFQNLLAKIC
1150
FYHHFSVVER
1160
VDSCASMYSR
1170
SIQGHHVCLL
1180
VKKGESSVSV
1190
DGKCSDATLL
1200
SSLLEEMKTT
LSQC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030123 | AP-3 adaptor complex |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:1904115 | axon cytoplasm |
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0098830 | presynaptic endosome |
| Cellular Component | GO:0043195 | terminal bouton |
| Biological Process | GO:0008089 | anterograde axonal transport |
| Biological Process | GO:0048490 | anterograde synaptic vesicle transport |
| Biological Process | GO:0019882 | antigen processing and presentation |
| Biological Process | GO:0048007 | antigen processing and presentation, exogenous lipid antigen via MHC class Ib |
| Biological Process | GO:0035646 | endosome to melanosome transport |
| Biological Process | GO:0006896 | Golgi to vacuole transport |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0098943 | neurotransmitter receptor transport, postsynaptic endosome to lysosome |
| Biological Process | GO:0051138 | positive regulation of NK T cell differentiation |
| Biological Process | GO:0072657 | protein localization to membrane |
| Biological Process | GO:0006605 | protein targeting |
| Biological Process | GO:0006623 | protein targeting to vacuole |
| Biological Process | GO:0016182 | synaptic vesicle budding from endosome |
| Biological Process | GO:0048499 | synaptic vesicle membrane organization |
| Biological Process | GO:0140916 | zinc ion import into lysosome |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.