Search Results
Overview
| Uniprot ID | B6CVD6 |
|---|---|
| Protein Name | Endoplasmic reticulum resident protein 44 |
| Gene Name | TXNDC4 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | AQRYRISKYPTLKLF |
| 130 | YRGQRSVKALADYIR |
| 183 | RVFERVAKILHDDCT |
| 303 | FLHADCDKFRHPLLH |
| 313 | HPLLHIQKTPADCPV |
| 343 | RDVLIPGKLKQFVFD |
| 345 | VLIPGKLKQFVFDLH |
Function
Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum
Protein Sequence
10
MNPAVFLSLP
20
DLRCSLLLLV
30
TWVFTPVTPE
40
ITSLDTENID
50
DILNNADVAL
60
VNFYADWCRF
70
SQMLHPIFEE
80
ASNVIKEEYP
90
NENQVVFARV
100
DCDQHSDIAQ
110
RYRISKYPTL
120
KLFRNGMMMK
130
REYRGQRSVK
140
ALADYIRQQK
150
SDPIQELHDL
160
AEITTLDRSK
170
RNIIGYFEQK
180
DSENYRVFER
190
VAKILHDDCT
200
FLSAFGAVSK
210
PERYSGDNIV
220
YKPPGHSAPD
230
MVYLGYMTNF
240
DGTFNWIQDK
250
CVPLVREITF
260
ENGEELTEEG
270
LPFLILFHMK
280
EDTESLEIFQ
290
NEVARQLISE
300
KGTINFLHAD
310
CDKFRHPLLH
320
IQKTPADCPV
330
IAIDSFRHMY
340
VFGDFRDVLI
350
PGKLKQFVFD
360
LHSGKLHREF
370
HHGPDPTDTA
380
PGQEVQDVAS
390
SPPESSFQKL
400
APSEYRYTLL
RDRDEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.