Search Results
Overview
| Uniprot ID | B6CVD7 |
|---|---|
| Protein Name | ERO1-like protein alpha |
| Gene Name | ERO1A |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 402 | LKCRLWGKLQTQGLG |
| 78 | SDYFRYYKVNLKRPC |
Function
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1
Protein Sequence
10
MGHRWGFLIV
20
FLGAVGLLGS
30
GYGRQQPSET
40
AAQRCFCQVS
50
GYLDDCTCDV
60
ETIDRFNNYR
70
LFPRLQKLLE
80
SDYFRYYKVN
90
LKRPCPFWND
100
INQCGRRDCA
110
VKPCQSDEIP
120
DGIKSASYKY
130
SEEANNLIEE
140
CEQAERLGAV
150
DESLSEETQK
160
AVLQWTKHDD
170
SSDNFCEADD
180
IQSPDAEYVD
190
LLLNPERYTG
200
YKGPDAWKIW
210
NVIYEENCFK
220
PQTIKRPLNP
230
LASGQGKSEE
240
NTFYSWLEGL
250
CVEKRAFYRL
260
ISGLHASINV
270
HLSARYLLQD
280
TWLEKKWGHN
290
ITEFQQRFDG
300
ILTEGEGPRR
310
LKNLYFLYLI
320
ELRALSKVVP
330
FFERPDFQLF
340
TGNKVQDAEN
350
KMLLLDILHE
360
IKSFPLHFDE
370
NSFFAGDKKE
380
ANKLKEDFRL
390
HFRNISRIMD
400
CVGCLKCRLW
410
GKLQTQGLGT
420
ALKILFSEKL
430
IANMPESGPS
440
YEFHLTRQEI
450
VSLFNAFGRI
460
STSVKELENF
RNLLQNIH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005796 | Golgi lumen |
| Molecular Function | GO:0071949 | FAD binding |
| Molecular Function | GO:0016971 | flavin-dependent sulfhydryl oxidase activity |
| Molecular Function | GO:0015035 | protein-disulfide reductase activity |
| Molecular Function | GO:0016972 | thiol oxidase activity |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0034975 | protein folding in endoplasmic reticulum |
| Biological Process | GO:0051209 | release of sequestered calcium ion into cytosol |
| Biological Process | GO:0034976 | response to endoplasmic reticulum stress |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.