Search Results

Overview

Uniprot ID	C0HKE1
Protein Name	Histone H2A type 1-B
Gene Name	H2ac4
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
96	RNDEELNKLLGRVTI

Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Protein Sequence

10 MSGRGKQGGK 20 ARAKAKTRSS 30 RAGLQFPVGR 40 VHRLLRKGNY 50 SERVGAGAPV 60 YLAAVLEYLT 70 AEILELAGNA 80 ARDNKKTRII 90 PRHLQLAIRN 100 DEELNKLLGR 110 VTIAQGGVLP 120 NIQAVLLPKK 130 TESHHKAKGK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0043505	CENP-A containing nucleosome
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0000786	nucleosome
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0046982	protein heterodimerization activity
Molecular Function	GO:0030527	structural constituent of chromatin
Biological Process	GO:0031507	heterochromatin formation

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.