Search Results
Overview
| Uniprot ID | C0LZL0 |
|---|---|
| Protein Name | Fascin |
| Gene Name | FSCN1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 220 | TLEFRSGKVAFRDCE |
| 241 | SGPSGTLKAGKATKV |
| 313 | AFRTHSGKYWTLTAS |
| 353 | ILRASNGKFVTAKKN |
| 399 | HGFIGCRKVTGTLDA |
| 41 | NASASSLKKKQIWTL |
| 426 | RDGAYNIKDSTGKYW |
| 464 | DYNKVAIKVGGHYLK |
| 471 | KVGGHYLKGDHAGVL |
| 74 | GRYLAADKDGNVTCE |
Function
Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF
Protein Sequence
10
MTANGTAEAL
20
QIQFGLINCS
30
NKYLTAETFG
40
FKVNASASSL
50
KKKQIWTLEQ
60
PPDEAGGAAM
70
CLRSHLGRYL
80
AADKDGNVTC
90
EHEVPDADCR
100
FLIVAHDDGR
110
WSLQSEAHRR
120
YFGGTEDRLS
130
CFAQTVSPAE
140
KWSVHIAMHP
150
QVNIYSLARK
160
RYAHLSARPA
170
DEISVDRDVP
180
WGVDSLITLA
190
FQDQRYSLQT
200
ADHRFLRHDG
210
RLVEQPEPAT
220
GYTLEFRSGK
230
VAFRDCEGRY
240
LAPSGPSGTL
250
KAGKATKVGK
260
DELFALEQSC
270
AQVVLQAANE
280
RNVSTRQGMD
290
LSANQDEETD
300
QETFQLEIDG
310
DTKKCAFRTH
320
SGKYWTLTAS
330
GGVQSTASSK
340
DASCYFDIEW
350
RDRRIILRAS
360
NGKFVTAKKN
370
GQLAASVETA
380
GDSELFLMKL
390
INRPIIVFRG
400
EHGFIGCRKV
410
TGTLDANRSN
420
YDVFQLEFRD
430
GAYNIKDSTG
440
KYWMVGTDSS
450
VTSSSDTPVD
460
FFFEFLDYNK
470
VAIKVGGHYL
480
KGDHAGVLKA
490
CADAIDPATL
WEY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0031253 | cell projection membrane |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0044393 | microspike |
| Cellular Component | GO:0005902 | microvillus |
| Cellular Component | GO:0002102 | podosome |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0001725 | stress fiber |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Biological Process | GO:0051017 | actin filament bundle assembly |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0007043 | cell-cell junction assembly |
| Biological Process | GO:0035089 | establishment of apical/basal cell polarity |
| Biological Process | GO:0007163 | establishment or maintenance of cell polarity |
| Biological Process | GO:0030035 | microspike assembly |
| Biological Process | GO:0030046 | parallel actin filament bundle assembly |
| Biological Process | GO:0090091 | positive regulation of extracellular matrix disassembly |
| Biological Process | GO:0051491 | positive regulation of filopodium assembly |
| Biological Process | GO:0010592 | positive regulation of lamellipodium assembly |
| Biological Process | GO:0071803 | positive regulation of podosome assembly |
| Biological Process | GO:0032534 | regulation of microvillus assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.