Search Results

Overview

Uniprot IDC7E1V1
Protein NameInositol 1,4,5-trisphosphate receptor
Gene NameItpr3
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1570 QRSAANYKTATRTFP
331 KGDVSDPKAAGPGAQ

Function

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium

Protein Sequence

10 MNEMSSFLHI 20 GDIVSLYAEG 30 SVNGFISTLG 40 LVDDRCVVEP 50 AAGDLDNPPK 60 KFRDCLFKVC 70 PMNRYSAQKQ 80 YWKAKQTKQD 90 KEKIADVVLL 100 QKLQHAAQME 110 QKQNDTENKK 120 VHGDVVKYGS 130 VIQLLHMKSN 140 KYLTVNKRLP 150 ALLEKNAMRV 160 TLDATGNEGS 170 WLFIQPFWKL 180 RSNGDNVVVG 190 DKVILNPVNA 200 GQPLHASNYE 210 LSDNVGCKEV 220 NSVNCNTSWK 230 INLFMQFRDH 240 LEEVLKGGDV 250 VRLFHAEQEK 260 FLTCDEYRGK 270 LQVFLRTTLR 280 QSATSATSSN 290 ALWEVEVVHH 300 DPCRGGAGHW 310 NGLYRFKHLA 320 TGNYLAAEEN 330 PSYKGDVSDP 340 KAAGPGAQSR 350 TGRRNAGEKI 360 KYRLVAVPHG 370 NDIASLFELD 380 PTTLQKTDSF 390 VPRNSYVRLR 400 HLCTNTWIQS 410 TNAPIDVEEE 420 RPIRLMLGTC 430 PTKEDKEAFA 440 IVSVPVSEIR 450 DLDFANDASS 460 MLASAVEKLN 470 EGFISQNDRR 480 FVIQLLEDLV 490 FFVSDVPNNG 500 QNVLDIMVTK 510 PNRERQKLMR 520 EQNILKQIFG 530 ILKAPFRDKG 540 GEGPLVRLEE 550 LSDQKNAPYQ 560 YMFRLCYRVL 570 RHSQEDYRKN 580 QEHIAKQFGM 590 MQSQIGYDIL 600 AEDTITALLH 610 NNRKLLEKHI 620 TKTEVETFVS 630 LVRKNREPRF 640 LDYLSDLCVS 650 NRIAIPVTQE 660 LICKCVLDPK 670 NSDILIQTEL 680 RPVKEMAQSH 690 EYLSIEYSEE 700 EVWLTWTDRN 710 NEHHEKSVRQ 720 LAQEARAGNA 730 HDENVLSYYR 740 YQLKLFARMC 750 LDRQYLAIDE 760 ISKQLGVELL 770 FLCMADEMLP 780 FDLRASFCHL 790 MLHVHVDRDP 800 QELVTPVKFA 810 RLWTEIPTAI 820 TIKDYDSNLN 830 ASRDDKKNKF 840 ASTMEFVEDY 850 LNNVVGEAVP 860 FANDEKNILT 870 FEVVSLAHNL 880 IYFGFYSFSE 890 LLRLTRTLLG 900 IIDCIQAPAA 910 VLQAYEEPGG 920 KNVRRSIQGV 930 GHMMSTMVLS 940 RKQSVFGASS 950 LPTGVGVPEQ 960 LDRSKFEDNE 970 HTVVMETKLK 980 ILEILQFILN 990 VRLDYRISYL 1000 LSVFKKEFVE 1010 VFPMQDSGAD 1020 GTAPAFDSST 1030 ANMNLDRIGE 1040 QAEAMFGVGK 1050 TSSMLEVDDE 1060 GGRMFLRVLL 1070 HLTMHDYPPL 1080 VSGALQLLFK 1090 HFSQRQEAMH 1100 TFKQVQLLIS 1110 AQDVENYKVI 1120 KSELDRLRTM 1130 VEKSELWVDK 1140 KGSVKGEEGE 1150 AGASKDKKER 1160 PSDEEGFLQP 1170 HGEKSSENYQ 1180 IVKGILERLN 1190 KMCGVGEQMR 1200 KKQQRLLKNM 1210 DAHKVMLDLL 1220 QIPYDKNDNK 1230 MMEILRYTHQ 1240 FLQKFCAGNP 1250 GNQALLHKHL 1260 QLFLTPGLLE 1270 AETMQHIFLN 1280 NYQLCSEISE 1290 PVLQHFVHLL 1300 ATHGRHVQYL 1310 DFLHTVIKAE 1320 GKYVKKCQDM 1330 IMTELTNAGD 1340 DVVVFYNDKA 1350 SLAHLLDMMK 1360 AARDGVEDHS 1370 PLMYHISLVD 1380 LLAACAEGKN 1390 VYTEIKCTSL 1400 LPLEDVVSVV 1410 THEDCITEVK 1420 MAYVNFVNHC 1430 YVDTEVEMKE 1440 IYTSNHIWTL 1450 FENFTLDMAL 1460 VCNKREKRLS 1470 DPTLEKYVLT 1480 VVLDTISAFF 1490 SSPFSENSTS 1500 LQTHQTIVVQ 1510 LLQSTTRLLE 1520 CPWLQQQHKG 1530 SVEACVRTLA 1540 MVAKSRAILL 1550 PMDLDAHMSA 1560 LLSSGGSCSA 1570 AAQRSAANYK 1580 TATRTFPRVI 1590 PTANQWDYKN 1600 IIEKLQDIIT 1610 ALEERLKPLV 1620 QAELSVLVDM 1630 LHWPELLFLE 1640 GSEAYQRCES 1650 GGFLSKLIRH 1660 TKGLMESEEK 1670 LCVKVLRTLQ 1680 QMLQKKSKYG 1690 DRGNQLRKML 1700 LQNYLQNRKS 1710 GPRGELTDPT 1720 GSGVDQDWSA 1730 IAATQCRLDK 1740 EGATKLVCDL 1750 ITSTKNEKIF 1760 QESIGLAIRL 1770 LDGGNTEIQK 1780 SFYNLMTSDK 1790 KSERFFKVLH 1800 DRMKRAQQET 1810 KSTVAVNMSD 1820 LGSQPREDRE 1830 PADPTTKGRV 1840 SSFSMPSSSR 1850 YSLGPGLHRG 1860 HDVSERAQNN 1870 EMGTSVLIMR 1880 PILRFLQLLC 1890 ENHNRDLQNF 1900 LRCQNNKTNY 1910 NLVCETLQFL 1920 DIMCGSTTGG 1930 LGLLGLYINE 1940 DNVGLVIQTL 1950 ETLTEYCQGP 1960 CHENQTCIVT 1970 HESNGIDIIT 1980 ALILNDISPL 1990 CKYRMDLVLQ 2000 LKDNASKLLL 2010 ALMESRHDSE 2020 NAERILISLR 2030 PQELVDVIKK 2040 AYLQEEEREN 2050 SEVSPREVGH 2060 NIYILALQLS 2070 RHNKQLQHLL 2080 KPVKRIQEEE 2090 AEGISSMLSL 2100 NNKQLSQMLK 2110 SSAPAQEEEE 2120 DPLAYYENHT 2130 SQIEIVRQDR 2140 SMEQIVFPVP 2150 AICQFLTEET 2160 KHRLFTTTEQ 2170 DEQGSKVSDF 2180 FDQSSFLHNE 2190 MEWQRRLRSM 2200 PLIYWFSRRM 2210 TLWGSISFNL 2220 AVFINIIIAF 2230 FYPYVEGAST 2240 GVLGSPLISL 2250 LFWILICFSI 2260 AALFTKHYSV 2270 RPLIVALVLR 2280 SIYYLGIGPT 2290 LNILGALNLT 2300 NKIVFVVSFV 2310 GNRGTFIRGY 2320 KAMVMDMEFL 2330 YHVGYILTSV 2340 LGLFAHELFY 2350 SILLFDLIYR 2360 EETLFNVIKS 2370 VTRNGRSILL 2380 TALLALILVY 2390 LFSIVGFLFL 2400 KDDFILEVDR 2410 LPGNHSRAST 2420 LGMPHGAATF 2430 MGTCSGDKMD 2440 CVSEVSVPEI 2450 LEEDEELDST 2460 ERACDTLLMC 2470 IVTVMNHGLR 2480 NGGGVGDILR 2490 KPSKDESLFP 2500 ARVVYDLLFF 2510 FIVIIIVLNL 2520 IFGVIIDTFA 2530 DLRSEKQKKE 2540 EILKTTCFIC 2550 GLERDKFDNK 2560 TVSFEEHIKL 2570 EHNMWNYLYF 2580 IVLVRVKNKT 2590 DYTGPESYVA 2600 QMIKNKNLDW 2610 FPRMRAMSLV 2620 SGEGEGEQNE 2630 IRILQEKLGS 2640 TMKLVSHLTA 2650 QLNELKEQMT 2660 EQRKRRQRLG 2670 FVDVQNCMSR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0030658 transport vesicle membrane
Molecular Function GO:0070679 inositol 1,4,5 trisphosphate binding
Molecular Function GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity
Biological Process GO:0051209 release of sequestered calcium ion into cytosol

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.