Search Results
Overview
| Uniprot ID | C9JLW8 |
|---|---|
| Protein Name | Mapk-regulated corepressor-interacting protein 1 |
| Gene Name | MCRIP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 14 | SRVVYNGKRTSSPRS |
Function
The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771)
Protein Sequence
10
MTSSPVSRVV
20
YNGKRTSSPR
30
SPPSSSEIFT
40
PAHEENVRFI
50
YEAWQGVERD
60
LRGQVPGGER
70
GLVEEYVEKV
80
PNPSLKTFKP
90
IDLSDLKRRS
TQDAKKS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0010494 | cytoplasmic stress granule |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Biological Process | GO:0010717 | regulation of epithelial to mesenchymal transition |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.