Overview
| Uniprot ID | C9JRZ8 |
|---|
| Protein Name | Aldo-keto reductase family 1 member B15 |
|---|
| Gene Name | AKR1B15 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 173 |
QIERLLNKPGLKYKP |
| 177 |
LLNKPGLKYKPVTNQ |
Function
Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:21276782, PubMed:26222439). In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs (PubMed:25577493). Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal (PubMed:26222439). May play a physiological role in retinoid metabolism (PubMed:26222439)
Protein Sequence
10
MATFVELSTK
20
AKMPIVGLGT
30
WRSLLGKVKE
40
AVKVAIDAEY
50
RHIDCAYFYE
60
NQHEVGEAIQ
70
EKIQEKAVMR
80
EDLFIVSKVW
90
PTFFERPLVR
100
KAFEKTLKDL
110
KLSYLDVYLI
120
HWPQGFKTGD
130
DFFPKDDKGN
140
MISGKGTFLD
150
AWEAMEELVD
160
EGLVKALGVS
170
NFNHFQIERL
180
LNKPGLKYKP
190
VTNQVECHPY
200
LTQEKLIQYC
210
HSKGITVTAY
220
SPLGSPDRPW
230
AKPEDPSLLE
240
DPKIKEIAAK
250
HKKTTAQVLI
260
RFHIQRNVTV
270
IPKSMTPAHI
280
VENIQVFDFK
290
LSDEEMATIL
300
SFNRNWRAFD
310
FKEFSHLEDF
PFDAEY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0004032 |
aldose reductase (NADPH) activity |
| Molecular Function |
GO:0052650 |
all-trans-retinol dehydrogenase (NADP+) activity |
| Molecular Function |
GO:0047655 |
allyl-alcohol dehydrogenase activity |
| Molecular Function |
GO:0004303 |
estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
| Molecular Function |
GO:0047886 |
farnesol dehydrogenase activity |
| Molecular Function |
GO:0016616 |
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| Molecular Function |
GO:0047045 |
testosterone dehydrogenase (NADP+) activity |
| Biological Process |
GO:0006703 |
estrogen biosynthetic process |
| Cellular Component |
GO:0005829 |
cytosol |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.