Search Results
Overview
| Uniprot ID | D0G0C1 |
|---|---|
| Protein Name | 1-acyl-sn-glycerol-3-phosphate acyltransferase delta |
| Gene Name | AGPAT4 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 119 | FGVLGGSKVLAKKEL |
Function
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA)
Protein Sequence
10
MDLVGLLKSQ
20
FLCHLVFCYV
30
FIASGLIINT
40
IQLFTLLLWP
50
INKQLFRRIN
60
CRLSYCISSQ
70
LVMLLEWWSG
80
TECVIHTDPR
90
AYPKYGKENA
100
IVVLNHKFEI
110
DFLCGWSLAE
120
RFGVLGGSKV
130
LAKKELAYVP
140
IIGWMWYFTE
150
MVFCTRKWEQ
160
DRKTVSRSLL
170
HLRDYPEKYF
180
FLIHCEGTRF
190
TEKKHQISMQ
200
VAQAKGLPSL
210
KHHLLPRTKG
220
FAVTVRSLRN
230
VVSAVYDCTL
240
NFRNNENPTL
250
LGVLNGKKYH
260
ADLYVRRIPL
270
EEVPEDEDKC
280
SAWLHKLYQE
290
KDAFQEEYCR
300
TGTFPETPMV
310
PPRRPWTLVN
320
WLFWASLLLY
330
PFVRFLVNMV
340
SSGSSLTLAG
350
FVLVFFVASM
360
GVRWMIGVTE
370
IDKGSAYGNM
DSKQKHSD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0012505 | endomembrane system |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Molecular Function | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity |
| Biological Process | GO:0008654 | phospholipid biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.