Search Results
Overview
| Uniprot ID | D0G6X4 |
|---|---|
| Protein Name | Farnesyl pyrophosphate synthase |
| Gene Name | FDPS |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 114 | GDAVARLKEVLEYNV |
| 125 | EYNVVGGKYNRGITV |
| 144 | RELVEPRKQDADSLQ |
| 365 | YGQKDAEKVARVKAL |
Function
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate
Protein Sequence
10
MLPLSRWLRS
20
VGLFLLPAPC
30
WVPRERWLGP
40
LRRPSLVHGC
50
PVLGAWHSAR
60
CWCQAWTEEP
70
RAFYSSLRMN
80
GDQKLDAYAR
90
ERQDFIQHFS
100
QIVKVLTEED
110
IGHPEIGDAV
120
ARLKEVLEYN
130
VVGGKYNRGI
140
TVLVVFRELV
150
EPRKQDADSL
160
QRALTVGWCI
170
ELLQAFFLVA
180
DDIEDSSLTR
190
RGQTCWYRKP
200
GIGLDAINDA
210
FLLEACIYRL
220
LKFYCREQPY
230
YLNLIELFLQ
240
TSYNTEIGQT
250
LDLIAGPQGN
260
VDLSRFTEKR
270
YKSIVKYKTA
280
FYSFYLPVAA
290
AMYMAGIDGE
300
KEHANAKKIL
310
MEMGEFFQIQ
320
DDYLDLFGDP
330
SVTGKIGTDI
340
QDNKCSWLVV
350
QCLQRASPEQ
360
RQILQENYGQ
370
KDAEKVARVK
380
ALYEEMNLQA
390
VFLQYEEDSY
400
SHLMGLIEQY
410
AAPLPPAIFL
420
ELAHKIYKRR
K
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0004337 | (2E,6E)-farnesyl diphosphate synthase activity |
| Molecular Function | GO:0004161 | dimethylallyltranstransferase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0033489 | cholesterol biosynthetic process via desmosterol |
| Biological Process | GO:0033490 | cholesterol biosynthetic process via lathosterol |
| Biological Process | GO:0010142 | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| Biological Process | GO:0033386 | geranylgeranyl diphosphate biosynthetic process |
| Biological Process | GO:0036197 | zymosterol biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.