Overview
| Uniprot ID | D0G6X8 |
|---|
| Protein Name | Beta-hexosaminidase |
|---|
| Gene Name | HEXB |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 381 |
NMISAMKKRPIVWQE |
Function
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida
Protein Sequence
10
MAMERHGWRW
20
LPGLLALLAA
30
LVVPKGWARD
40
TSGAESLGLW
50
PLPFAVDISP
60
RSLHLSPNNF
70
FFGHSPTSKA
80
GSSCEILQEA
90
FRRYYDFIFG
100
FYKWHQGSYQ
110
LCFGTELQQL
120
QVHVESECDT
130
FPSISSNESY
140
VLHVKGPEAL
150
LRANTVWGAL
160
RGLETFSQLI
170
YQDSYGTFTV
180
NESEIIDFPR
190
FPHRGILIDT
200
GRHFLSVKTI
210
FKTLDAMAFN
220
KFNVLHWHIV
230
DDQSFPYQSI
240
NFPLLSSKGS
250
YSLSHVYTPN
260
DVRMVIEYAR
270
IRGIRVMPEF
280
DTPGHSRSWG
290
KGQKDLLTPC
300
YRKQVLSGTF
310
GPINPILNTT
320
YNFLSKFFKE
330
ISTVFPDEFI
340
HIGGDEVDFD
350
CWASNSEILQ
360
FMQEKGFSKN
370
FTKLQSFYVF
380
KISNMISAMK
390
KRPIVWQEAF
400
DGRDKFMPGT
410
VVQVWKIEDY
420
KWEQSLITKA
430
GFPVILSAPW
440
YLDLISYGQD
450
WKNYYEVEPQ
460
DFPGSDKERK
470
RVLGGEACLW
480
GEYVDATNLT
490
PRLWPRASAV
500
GERLWSHKDV
510
RDIHDAYSRL
520
TIHRCRMVRR
530
GIAAEPLFTG
YCNHEHRM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0001669 |
acrosomal vesicle |
| Cellular Component |
GO:0042582 |
azurophil granule |
| Cellular Component |
GO:0060473 |
cortical granule |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0005764 |
lysosome |
| Cellular Component |
GO:0016020 |
membrane |
| Molecular Function |
GO:0008375 |
acetylglucosaminyltransferase activity |
| Molecular Function |
GO:0004563 |
beta-N-acetylhexosaminidase activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Biological Process |
GO:0043615 |
astrocyte cell migration |
| Biological Process |
GO:0005975 |
carbohydrate metabolic process |
| Biological Process |
GO:0030207 |
chondroitin sulfate proteoglycan catabolic process |
| Biological Process |
GO:0030209 |
dermatan sulfate proteoglycan catabolic process |
| Biological Process |
GO:0006689 |
ganglioside catabolic process |
| Biological Process |
GO:0030203 |
glycosaminoglycan metabolic process |
| Biological Process |
GO:0030214 |
hyaluronan catabolic process |
| Biological Process |
GO:0006491 |
N-glycan processing |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0008360 |
regulation of cell shape |
| Biological Process |
GO:0007338 |
single fertilization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.