Overview
| Uniprot ID | D3K5L7 |
|---|
| Protein Name | Pachytene checkpoint protein 2 homolog |
|---|
| Gene Name | TRIP13 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 190 |
TGKTSLCKALAQKLT |
| 195 |
LCKALAQKLTIRLSS |
| 379 |
LLSEISRKSEGLSGR |
Function
Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Plays a role in mitotic spindle assembly checkpoint (SAC) activation (By similarity)
Protein Sequence
10
MDEAVGDLKQ
20
ALPCVAEAPT
30
VHVEVHQRSG
40
STAKKEDVKL
50
NVRKLLNRHN
60
IVFGDYTWTE
70
FDEPFLTRNV
80
QSVSIVDTEL
90
KVKDPQPIDL
100
STCTVALHVF
110
QLNEGGPSSE
120
NLEEETENII
130
AANHWLLPAA
140
EFHGLWDSLV
150
YDAEVKSHLL
160
DYVMTTLLFS
170
DKNVDSNLIT
180
WNRVVLLHGP
190
PGTGKTSLCK
200
ALAQKLTIRL
210
SSRYRYGQLI
220
EINSHSLFSK
230
WFSESGKLVT
240
RMFQMIQDLI
250
DDKDALVFVL
260
IDEVESLTAA
270
RNACRAGTEP
280
SDAIRVVNAV
290
LTQIDQIKRH
300
SNVVILTTSN
310
ITERIDVAFV
320
DRADIRQYVG
330
PPSAAAIFKI
340
YLSCLEELMK
350
CQIIYPRQQL
360
LTLRELEMIG
370
FIENNVSKLS
380
LLLSEISRKS
390
EGLSGRVLRK
400
LPFLAHALYI
410
QAPTVTIEGF
420
LQALSLAVDR
430
QFEDRKKLSC
V
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005694 |
chromosome |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Biological Process |
GO:0006302 |
double-strand break repair |
| Biological Process |
GO:0051598 |
meiotic recombination checkpoint signaling |
| Biological Process |
GO:0007094 |
mitotic spindle assembly checkpoint signaling |
| Biological Process |
GO:0048477 |
oogenesis |
| Biological Process |
GO:0007131 |
reciprocal meiotic recombination |
| Biological Process |
GO:0007283 |
spermatogenesis |
| Biological Process |
GO:0007130 |
synaptonemal complex assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.